个人简介
教育经历
- 2002-09~2005-07,华南农业大学,动物遗传,博士
- 1999-09~2002-07,华南农业大学,动物遗传,硕士
- 1995-09~1999-07,华南农业大学,畜牧,学士
招生信息
- 专业学位硕导,生物科学与工程学院,086000,生物与医药,生物工程
- 专业学位硕导,生物科学与工程学院,105500,药学
- 学术型博导,生物科学与工程学院,071000,生物学,生物化学与分子生物学
- 学术型硕导,生物科学与工程学院,071000,生物学,生物化学与分子生物学
工作经历
- 2006-01,华南理工大学
- 2006-01~2024-11,华南理工大学
社会、学会及学术兼职
研究领域
科研
国家重点研发计划项目负责人，国内较早从事基因组的研究人员之一。作为2009年华工华大第一届基因组科学创新班班主任，借助华南理工大学与华大基因联合培养硕、博士的契机，已培养出高通量测序研究和应用型人才超100人，他们在华大基因、金域检验、达安基因等基因检测龙头企业发挥中流砥柱的作用。迄今主持或参与国家重点研发、重大专项和科技支撑等各类项目20余项；在Nat Biotechnol、Bioinformatics、Frontiers in Immunology、Journal of Chemical Information and Modeling、Computational and Structural Biotechnology Journal、Cancers、Front Psychol等国际著名杂志发表SCI论文70余篇，总引逾2500 次；申请发明专利10项，授权4项，获软件著作权16项，获省部级科技进步二等奖1项。Briefings in Bioinformatics、eBioMedicine、Theranostics、Molecular Therapy - Nucleic Acids、Computational and Structural Biotechnology Journal、Human Genetics、Frontiers in Immunology、Frontiers in Oncology、BMC Cancer、Frontiers in Genetics、International Journal of Infectious Diseases 等杂志评委。
科研兴趣：
（1）基于人工智能的多组学大数据分析技术开发与应用；
（2）基于组织、单细胞和时空多组学大数据以及系统生命调控的肿瘤和传染病机制揭示和治疗靶标鉴定；
（3）基于人工智能的高通量小分子药物筛选设计和修饰siRNA药物设计筛选；
（4）基于组学的肿瘤早期诊断和精准用药诊断方法和工具开发及应用。
开授课程
教学
本科生教学：基因组学、系统生物学
研究生教学：分子遗传学、分子生物学
科研项目
科研项目：
[1]主持国家重点研发项目：医学生命组学数据质量控制关键技术研发与应用（2018-2021）
[2]主持广东省重点领域项目：多组学整合技术研发及标准化组学数据质量控制技术的推广应用（2019-2022）
[3] 参与十二五重大专项（副组长）：人类重大疾病灵长类动物模型资源平台的建设（2011-2013）
[4] 主持广东省科技计划项目：食蟹猴2型糖尿病模型构建和评价体系的建立和完善（2012-2013）
[5] 主持国家自然科学基金：食蟹猴2型糖尿病模型发病进程的分子机制研究（2014）
[6] 参与科技支撑项目：灵长类动物人类重大疾病模型的研究与示范（2014-2016）
[7] 参与科技支撑项目：实验动物感染病原的MFIA、PCR-HRM、基因芯片检测诊断和遗传质量SNP检测的新技术方法研究和应用（2015-2017）
论文
- Yin, Feng;Yang, Jing;Luo, Hao;Yu, Tiantian;Lu, Wenhua;Zhao, Mingyue;Du, Hongli;Wen, Shijun;Huang, Peng;Hu, Yumin,Targeting oncogenic activation of FLT3/SREBP/FASN promotes the therapeutic effect of quizartinib involving disruption of mitochondrial phospholipids,Cell Death & Disease,2025
- Tan, Wenchong;Dai, Mingshu;Ye, Shimin;Tang, Xin;Jiang, Dawei;Chen, Dong;Du, Hongli,ENsiRNA: A Multimodality Method for siRNA-mRNA and Modified siRNA Efficacy Prediction Based on Geometric Graph Neural Network,Journal of Molecular Biology,2025
- Yang, Zhengning; Meng, Zhongxuan; Liu, Shangyuan; Chen, Yuxin; Gan, Xuhong; Zhang, Zi-Mei; Luo, Xiaoshan; Yan, Jiahong; Chen, Huijin; Huang, Danqing; Huang, Lihong; Zeng, Xiaomin; Ma, Wenyu; Liu, Jun; Wang, Linlin; Huang, Haotian; Yang, Xinyi; Hu, Mei; Chen, Lin; Du, Hongli,LTO1 and YAE1 regulate MHC-I expression via nonsense-mediated RNA decay in tumor cells,Journal for ImmunoTherapy of Cancer,2025
- Xi, Binbin;Hua, Zhihao;Jiang, Dawei;Chen, Zixi;Wei, Jinfen;Meng, Yuhuan;Du, Hongli,Within-Host Fitness and Antigenicity Shift Are Key Factors Influencing the Prevalence of Within-Host Variations in the SARS-CoV-2 S Gene,Viruses-Basel,2025
- 张利刚;唐冬生;杜红丽,铜代谢和铜死亡的分子机制及相关疾病治疗研究,佛山科学技术学院学报(自然科学版),2025
- Cai, Yi;Zhang, Qian;Tan, Wenchong;Li, Jing;Chen, Dong;Lu, Xiaoyun;Du, Hongli,Comprehensive Drug-Likeness Prediction Using a Pretrained Transformer Model and Multitask Learning,Journal of Chemical Information and Modeling,2025
- Xie, Jianling; Shen, Kaikai; Liang, Wenken; Kuang, Zijian; Shrestha, Raj K.; Hanson, Adrienne R.; Townley, Scott L.; He, Meiling; Yu, Sishu; Zhou, Peiwen; Zhu, Liangzhen; Gong, Zhiwen; Ao, Xiang; Rao, Sushma R.; Zhang, Qing; Chen, Kaijie; Wei, Jinfen; Marri, Shashikanth; Snel, Marten F.; Irani, Swati,Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival,Proceedings of the National Academy of Sciences of the United States of America,2025
- Jiang Dawei;Chen Zixi;Du Hongli,Cyclic peptide membrane permeability prediction using deep learning model based on molecular attention transformer,Frontiers in Bioinformatics,2025
- Wan, Yanbin;Huang, Caimei;Feng, Dongyan;Wang, Lv;Lin, Xiding;Zhao, Xuanye;Han, Liya;Zhu, Yanyu;Hao, Lijing;Du, Hongli;Huang, Lizhen*,Characterizing the collateral activity of CRISPR/Cas13 in mammalian cells: Implications for RNA editing and therapeutic applications,International Journal of Biological Macromolecules,2024
- Gong, Xiaocheng;Liu, Yunfei;Liang, Keying;Chen, Zixi;Ding, Ke;Qiu, Li;Wei, Jinfen;Du, Hongli,Cucurbitacin I exerts its anticancer effects by inducing cell cycle arrest via the KAT2a-ube2C/E2F1 pathway and inhibiting HepG2-induced macrophage M2 polarization,Biochemical and Biophysical Research Communications,2024
- Zhang, Ligang;Deng, Ruiting;Guo, Raoqing;Jiang, Yawen;Guan, Yichen;Chen, Caiyue;Zhao, Wudi;Huang, Guobin;Liu, Lian;Du, Hongli;Tang, Dongsheng,Recent progress of methods for cuproptosis detection,Frontiers in Molecular Biosciences,2024
- Zhang, Ligang;Deng, Ruiting;Liu, Lian;Du, Hongli;Tang, Dongsheng,Novel insights into cuproptosis inducers and inhibitors,Frontiers in Molecular Biosciences,2024
- Fu, Shuying;Gong, Xiaocheng;Liang, Keying;Ding, Ke;Qiu, Li;Cen, Huice;Du, Hongli,KLF3 impacts insulin sensitivity and glucose uptake in skeletal muscle,American Journal of Physiology - Cell Physiology,2024
- Yang, Fang;Lin, Qianmeng;Song, Xiaojuan;Huang, Huisi;Chen, Xiaojuan;Tan, Jianwen;Li, Yun;Zhou, Yang;Tu, Zhengchao;Du, Hongli;Zhang, Zhi-min;Ortega, Raquel;Lin, Xiaojing;Patterson, Adam V.;Smaill, Jeff B.;Chen, Yongheng;Lu, Xiaoyun,Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity,Journal of Medicinal Chemistry,2024
- Qu, Yimo;Gong, Xiaocheng;Zhao, Ziyuan;Zhang, Zimei;Zhang, Qian;Huang, Yuting;Xie, Qingsong;Liu, Yunfei;Wei, Jinfen;Du, Hongli,Establishment and Validation of Novel Prognostic Subtypes in Hepatocellular Carcinoma Based on Bile Acid Metabolism Gene Signatures Using Bulk and Single-Cell RNA-Seq Data,International Journal of Molecular Sciences,2024
- Jiang, Dawei;Xi, Binbin;Tan, Wenchong;Chen, Zixi;Wei, Jinfen;Hu, Meiling;Lu, Xiaoyun;Chen, Dong;Cai, Hongmin;Du, Hongli,NeoaPred: a deep-learning framework for predicting immunogenic neoantigen based on surface and structural features of peptide-human leukocyte antigen complexes,Bioinformatics,2024
- Gong, Xiaocheng;Liu, Yunfei;Zhang, Qian;Liang, Keying;Wei, Jinfen;Du, Hongli,LHFPL2 Serves as a Potential Biomarker for M2 Polarization of Macrophages in Renal Cell Carcinoma,International Journal of Molecular Sciences,2024
- Zhang, Zi-Mei;Huang, Yuting;Liu, Guanghao;Yu, Wenqi;Xie, Qingsong;Chen, Zixi;Huang, Guanda;Wei, Jinfen;Zhang, Haibo;Chen, Dong;Du, Hongli,Development of machine learning-based predictors for early diagnosis of hepatocellular carcinoma,Scientific Reports,2024
- Wei Jinfen;Yu Wenqi;Chen Juanzhi;Huang Guanda;Zhang Lingjie;Chen Zixi;Hu Meiling;Gong Xiaocheng;Du Hongli,Single-cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE+CTSZ+TAM in cancers,Molecular Oncology,2023
- Lin, Cailing;Chen, Feng;Huang, Dongchao;Li, Wenyan;He, Changsheng;Tang, Yingjun;Li, Xueping;Liu, Can;Han, Liya;Yang, Yunpeng;Zhu, Yongchong;Chen, Ruikang;Shi, Yuanju;Xia, Chenglai;Yan, Zhibin;Du, Hongli;Huang, Lizhen,A universal all-in-one RPA-Cas12a strategy with de novo autodesigner and its application in on-site ultrasensitive detection of DNA and RNA viruses,Biosensors and Bioelectronics,2023
- Liang, Keying;Wang, Qian;Qiu, Li;Gong, Xiaocheng;Chen, Zixi;Zhang, Haibo;Ding, Ke;Liu, Yunfei;Wei, Jinfen;Lin, Shudai;Fu, Shuying;Du, Hongli,Combined Inhibition of UBE2C and PLK1 Reduce Cell Proliferation and Arrest Cell Cycle by Affecting ACLY in Pan-Cancer,International Journal of Molecular Sciences,2023
- Lin Cailing;Chen Feng;Huang Dongchao;Li Wenyan;He Changsheng;Tang Yingjun;Li Xueping;Liu Can;Han Liya;Yang Yunpeng;Zhu Yongchong;Chen Ruikang;Shi Yuanju;Xia Chenglai;Yan Zhibin;Du Hongli;Huang Lizhen,A universal all-in-one RPA-Cas12a strategy with de novo autodesigner and its application in on-site ultrasensitive detection of DNA and RNA viruses,Biosensors and Bioelectronics,2023
- Wei, Jinfen;Yu, Wenqi;Wu, Lei;Chen, Zixi;Huang, Guanda;Hu, Meiling;Du, Hongli,Intercellular Molecular Crosstalk Networks within Invasive and Immunosuppressive Tumor Microenvironment Subtypes Associated with Clinical Outcomes in Four Cancer Types,Biomedicines,2023
- Xi Binbin;Zeng Xi;Chen Zixi;Zeng Jiong;Huang Lizhen;Du Hongli,SARS-CoV-2 within-host diversity of human hosts and its implications for viral immune evasion.,mBio,2023
- Xi, Binbin;Zeng, Xi;Chen, Zixi;Zeng, Jiong;Huang, Lizhen;Du, Hongli,SARS-CoV-2 within-host diversity of human hosts and its implications for viral immune evasion,mBio,2023
- Yao Yao;Wang Xueping;Guan Jian;Xie Chuanbo;Zhang Hui;Yang Jing;Luo Yao;Chen Lili;Zhao Mingyue;Huo Bitao;Yu Tiantian;Lu Wenhua;Liu Qiao;Du Hongli;Liu Yuying;Huang Peng;Luan Tiangang;Liu Wanli;Hu Yumin,Metabolomic differentiation of benign vs malignant pulmonary nodules with high specificity via high-resolution mass spectrometry analysis of patient sera,Nature Communications,2023
- Cao, Yanan; Chen, Lingling; Chen, Hua; Cun, Yupeng; Dai, Xiaofeng; Du, Hongli; Gao, Feng; Guo, Fengbiao; Guo, Yalong; Hao, Pei; He, Shunmin; He, Shunping; He, XiongLei; Hu, Zheng; Hoh, Boon-Peng; Jin, Xin; Jiang, Qian; Jiang, Qinghua; Khan, Asifullah; Kong, Hong-Zhi,Was Wuhan the early epicenter of the COVID-19 pandemic?-A critique,National Science Review,2023
- Yao, Yao;Wang, Xueping;Guan, Jian;Xie, Chuanbo;Zhang, Hui;Yang, Jing;Luo, Yao;Chen, Lili;Zhao, Mingyue;Huo, Bitao;Yu, Tiantian;Lu, Wenhua;Liu, Qiao;Du, Hongli;Liu, Yuying;Huang, Peng;Luan, Tiangang;Liu, Wanli;Hu, Yumin,Metabolomic differentiation of benign vs malignant pulmonary nodules with high specificity via high-resolution mass spectrometry analysis of patient sera,Nature Communications,2023
- Gong, Xiaocheng;Liu, Yunfei;Liang, Keying;Chen, Zixi;Ding, Ke;Qiu, Li;Wei, Jinfen;Du, Hongli,Cucurbitacin I Reverses Tumor-Associated Macrophage Polarization to Affect Cancer Cell Metastasis,International Journal of Molecular Sciences,2023
- Yanan Cao; Lingling Chen; Hua Chen; Yupeng Cun; Xiaofeng Dai; Hongli Du; Feng Gao; Fengbiao Guo; Yalong Guo; Pei Hao; Shunmin He; Shunping He; XiongLei He; Zheng Hu; Boon-Peng Hoh; Xin Jin; Qian Jiang; Qinghua Jiang; Asifullah Khan; Hong-Zhi Kong,Was Wuhan the early epicenter of the COVID-19 pandemic?——a critique,National Science Review,2023
- Yanan Cao; Lingling Chen; Hua Chen; Yupeng Cun; Xiaofeng Dai; Hongli Du; Feng Gao; Fengbiao Guo; Yalong Guo; Pei Hao; Shunmin He; Shunping He; XiongLei He; Zheng Hu; Boon-Peng Hoh; Xin Jin; Qian Jiang; Qinghua Jiang; Asifullah Khan; Hong-Zhi Kong,Was Wuhan the early epicenter of the COVID-19 pandemic?——a critiqueOA,National Science Review,2023
- Lu Shaohua;Lu Hong;Zheng Tingkai;Yuan Huiming;Du Hongli;Gao Youhe;Liu Yongtao;Pan Xuanzhen;Zhang Wenlu;Fu Shuying;Sun Zhenghua;Jin Jingjie;He QingYu;Chen Yang;Zhang Gong,A multi-omics dataset of human transcriptome and proteome stable reference.,Scientific data,2023
- Wei Jinfen;Yu Wenqi;Chen Juanzhi;Huang Guanda;Zhang Lingjie;Chen Zixi;Hu Meiling;Gong Xiaocheng;Du Hongli,Single-cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE+CTSZ+TAM in cancers.,Molecular oncology,2023
- Lu, Shaohua;Lu, Hong;Zheng, Tingkai;Yuan, Huiming;Du, Hongli;Gao, Youhe;Liu, Yongtao;Pan, Xuanzhen;Zhang, Wenlu;Fu, Shuying;Sun, Zhenghua;Jin, Jingjie;He, Qing-Yu;Chen, Yang;Zhang, Gong,A multi-omics dataset of human transcriptome and proteome stable reference,Scientific Data,2023
- Wei, Jinfen;Yu, Wenqi;Chen, Juanzhi;Huang, Guanda;Zhang, Lingjie;Chen, Zixi;Hu, Meiling;Gong, Xiaocheng;Du, Hongli,Single-cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE plus CTSZ plus TAM in cancers,Molecular Oncology,2023
- Xi, Binbin;Meng, Yuhuan;Jiang, Dawei;Bai, Yunmeng;Chen, Zixi;Qu, Yimo;Li, Shuhua;Wei, Jinfen;Huang, Lizhen;Du, Hongli,Analyses of Long-Term Epidemic Trends and Evolution Characteristics of Haplotype Subtypes Reveal the Dynamic Selection on SARS-CoV-2,Viruses-Basel,2022
- Lin, Shudai;Qiu, Li;Liang, Keying;Zhang, Haibo;Xian, Mingjian;Chen, Zixi;Wei, Jinfen;Fu, Shuying;Gong, Xiaocheng;Ding, Ke;Zhang, Zihao;Hu, Bowen;Zhang, Xiquan;Duan, Yuyou;Du, Hongli,KAT2A/E2F1 Promotes Cell Proliferation and Migration via Upregulating the Expression of UBE2C in Pan-Cancer,Genes,2022
- Lai, Yanzhen;Wang, Yu;Wu, Yaxian;Wu, Meng;Xing, Shan;Xie, Ying;Chen, Shulin;Li, Xiaohui;Zhang, Ao;He, Yi;Li, Huilan;Dai, Shuqin;Wang, Junye;Lin, Shudai;Bai, Yunmeng;Du, Hongli;Liu, Wanli,Identification and Validation of Serum CST1 as a Diagnostic Marker for Differentiating Early-Stage Non-Small Cell Lung Cancer from Pulmonary Benign Nodules,Cancer Control,2022
- Tang, Deyou;Li, Yucheng;Tan, Daqiang;Fu, Juan;Tang, Yelei;Lin, Jiabin;Zhao, Rong;Du, Hongli;Zhao, Zhongming,KCOSS: an ultra-fast k-mer counter for assembled genome analysis,Bioinformatics,2022
- Wei, Jinfen;Xie, Qingsong;Qu, Yimo;Huang, Guanda;Chen, Zixi;Du, Hongli,scWizard: A web-based automated tool for classifying and annotating single cells and downstream analysis of single-cell RNA-seq data in cancers,Computational and Structural Biotechnology Journal,2022
- He, Changsheng;Lin, Cailing;Mo, Guosheng;Xi, Binbin;Li, Anan;Huang, Dongchao;Wan, Yanbin;Chen, Feng;Liang, Yufeng;Zuo, Qingxia;Xu, Wanqing;Feng, Dongyan;Zhang, Guanting;Han, Liya;Ke, Changwen;Du, Hongli;Huang, Lizhen,Rapid and accurate detection of SARS-CoV-2 mutations using a Cas12a-based sensing platform,Biosensors and Bioelectronics,2022
- Xu, Wanqing;Zuo, Qingxia;Feng, Dongyan;He, Changsheng;Lin, Cailing;Huang, Dongchao;Wan, Yanbin;Chen, Feng;Mo, Guosheng;Sun, Qi;Du, Hongli;Huang, Lizhen,Validation Study to Determine the Accuracy of Widespread Promoterless EGFP Reporter at Assessing CRISPR/Cas9-Mediated Homology Directed Repair,Current Issues in Molecular Biology,2022
- Wei, Jinfen;Hu, Meiling;Du, Hongli,Improving Cancer Immunotherapy: Exploring and Targeting Metabolism in Hypoxia Microenvironment,Frontiers in Immunology,2022
- Jin, Jingjie;Chen, Zixi;Liu, Jinchao;Du, Hongli;Zhang, Gong,Towards an accurate and robust analysis pipeline for somatic mutation calling,Frontiers in Genetics,2022
- Zuo, Qingxia;Xu, Wanqing;Wan, Yanbin;Feng, Dongyan;He, Changsheng;Lin, Cailing;Huang, Dongchao;Chen, Feng;Han, Liya;Sun, Qi;Chen, Dong;Du, Hongli;Huang, Lizhen,Efficient generation of a CYP3A4-T2A-luciferase knock-in HepaRG subclone and its optimized differentiation,Biomedicine & Pharmacotherapy,2022
- Wei Jinfen;Hu Meiling;Du Hongli,Improving Cancer Immunotherapy: Exploring and Targeting Metabolism in Hypoxia Microenvironment,Frontiers in Immunology,2022
- Ding Ke;He Youhua;Wei Jinfen;Fu Shuying;Wang Jiajian;Chen Zixi;Zhang Haibo;Qu Yimo;Liang Keying;Gong Xiaocheng;Qiu Li;Chen Dong;Xiao Botao;Du Hongli,A score of DNA damage repair pathway with the predictive ability for chemotherapy and immunotherapy is strongly associated with immune signaling pathway in pan-cancer,Frontiers in Immunology,2022
- Ding, Ke;He, Youhua;Wei, Jinfen;Fu, Shuying;Wang, Jiajian;Chen, Zixi;Zhang, Haibo;Qu, Yimo;Liang, Keying;Gong, Xiaocheng;Qiu, Li;Chen, Dong;Xiao, Botao;Du, Hongli,A score of DNA damage repair pathway with the predictive ability for chemotherapy and immunotherapy is strongly associated with immune signaling pathway in pan-cancer,Frontiers in Immunology,2022
- He Changsheng;Lin Cailing;Mo Guosheng;Xi Binbin;Li An′an;Huang Dongchao;Wan Yanbin;Chen Feng;Liang Yufeng;Zuo Qingxia;Xu Wanqing;Feng Dongyan;Zhang Guanting;Han Liya;Ke Changwen;Du Hongli;Huang Lizhen,Rapid and accurate detection of SARS-CoV-2 mutations using a Cas12a-based sensing platform,Biosensors and Bioelectronics,2022
- Wei Jinfen;Xie Qingsong;Qu Yimo;Huang Guanda;Chen Zixi;Du Hongli,scWizard: A web-based automated tool for classifying and annotating single cells and downstream analysis of single-cell RNA-seq data in cancers,Computational and Structural Biotechnology Journal,2022
出版专著和教材
专利
获奖、荣誉称号
软著