个人简介
王志仁博士,华南理工大学国际校区生物医学科学与工程学院教授,课题组组长/PI,博士生导师,国家优秀青年科学基金项目(海外)获得者。2016年于中山大学药学院获博士学位,随后前往美国加州大学San Diego分校从事博士后研究,2019-2024年在美国亚利桑那大学药学院完成博士后训练。课题组研究方向主要基于药物化学、药物递送及纳米医学等,致力于新型磷脂及其前药分子技术的开发、构建脂质体药物制剂平台及其在药物递送、肿瘤免疫治疗以及神经退行性疾病创新疗法等方面。近年来,以第一或通讯作者在Nature Nanotechnology (IF: 40.5)、Nature Cancer (IF: 28.5)、Nature Communications (2篇,IF: 16.6)、Biomaterials (IF: 15.3)、Journal of Controlled Release (IF: 11.4)、Journal of Medicinal Chemistry等学术期刊发表20余篇研究论文,申请专利5项,获授权新型药物分子发明专利3项。 具体情况参见: https://www2.scut.edu.cn/bmse/2019/1216/c26925a570358/page.htm
工作经历
- 2019-08~2024-11,美国亚利桑那大学
- 2017-07~2017-12,中山大学药学院
- 2016-07~2016-11,美国加州大学圣地亚哥分校
科研项目
1.国家优秀青年科学基金(海外) 2.国家自然科学基金面上项目(32571605) 3.国家自然科学基金青年项目(21807033)
论文
- Zhiren Wang,Immunogenic camptothesome nanovesicles comprised by sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy,Nature Nanotechnology ,2021
- Zhiren Wang,A sphingolipid-derived Paclitaxel nanovesicle enhances efficacy of combination therapies in triple negative breast cancer and pancreatic cancer,Nature Cancer,2025.08.21
- Zhiren Wang,A sphingolipid-derived paclitaxel nanovesicle for improved cancer therapy,Nature Cancer,2025.09.04
- Zhiren Wang,Cholesterol-modified sphingomyelin chimeric lipid bilayer for fortified therapeutic delivery,Nature Communications,2024
- Zhiren Wang,Sphingomyelin-derived nanovesicles for the delivery of the IDO1 inhibitor epacadostat enhance metastatic and post-surgical melanoma immunotherapy,Nature Communications,2023
- Zhiren Wang,Camptothesome-based combination nanotherapeutic regimen for improved colorectal cancer immunochemotherapy,Biomaterials,2024
- Zhiren Wang,Camptothesome elicits immunogenic cell death to boost colorectal cancer immune checkpoint blockade,Journal of Controlled Release,2022
- Zhiren Wang,Design, synthesis, and evaluation of orally bioavailable quinoline–indole derivatives as innovative multitarget-directed ligands: promotion of cell proliferation in the adult murine hippocampus for the treatment of Alzheimer’s disease,Journal of Medicinal Chemistry ,2018
- Zhiren Wang,Design, synthesis and evaluation of orally available clioquinol-moracin M hybrids as multi-target-directed ligands for cognitive improvement in a rat model of neurodegeneration in Alzheimer’s disease,Journal of Medicinal Chemistry ,2015
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