个人简介
血细胞发育是一个多因子调控的复杂过程，异常的发育或功能可能导致严重的血液疾病，如白血病等，对人类健康构成严重威胁。然而，目前对于人群血液疾病基因变异的了解还十分有限，且缺乏有效的治疗药物。因此，明确造血发育与疾病的调控分子机制，并建立和优化高通量药物筛选体系，成为突破临床疾病治疗瓶颈的关键。在这一背景下，基于斑马鱼疾病模型的活体高通量药物筛选技术展现出独特的优势。
本人在遗传筛选与血细胞发育领域积累了丰富经验，通过“突变体筛选-发育机制解析-疾病模型构建-药物发现与评估”的系统性工作，发表SCI 30余篇，引用超300次，H指数11。以第一作者或通讯作者的身份，在Nature Communications（IF:14）、Blood(IF:23)、Leukemia(IF:13)、Haematologica(IF:8)和JBC等国际知名期刊上发表了原创性研究成果。主持两项国家自然科学基金项目，两项省部级项目，一项重点研发项目骨干（95万），参与两项国家重点研发项目。
教育经历
2005-2010，南方医科大学，本科 2010-2015，南方医科大学，硕博连读
招生信息
学术型硕导,医学院（生命科学研究院）,071000,生物学,细胞生物学 学术型博导,医学院（生命科学研究院），1001，基础医学，发育缺陷性疾病模型与药物筛选
工作经历
- 2017.07~至今,华南理工大学
- 2015.06~2017.07,南方医科大学
研究领域
多年来致力于斑马鱼早期血细胞发育研究和斑马鱼人类白血病疾病模型的建立研究并完成“突变体筛选—发育机制解析—疾病模型构建—药物筛选和和评估”的系统性工作：1.正反向遗传筛选获得斑马鱼白细胞发育缺陷突变体；2.利用筛选得到的白细胞缺陷突变体解析了白细胞发育中关键转录因子的作用机制；3.在解析发育机制的基础上进一步建立了斑马鱼人类白血病疾病模型，并阐述其发病机制，进行大规模白血病诱导分化药物筛选。
科研项目
1.国家重点研发计划子课题, 2024YFA1802201，心脑血管发育与稳态维持的调控规律，2024.12-2029.11，802万，在研，参与，个人经费95万。 2.国家重点研发计划子课题, 2023YFA1800103，血细胞类群发育及互作异常在相关疾病发生发展过程中的作用，2023.12-2028.11，693万，在研，参与，个人经费30万。 3.国家重点研发计划子课题, 2018YFA0801003，血液发育相关转录因子突变体系统研制，2019.09-2024.08，403万，结题，参与，人个经费65万。 4.国家自然科学基金面上项目，gcp6基因在斑马鱼造血干细胞发育中的作用，32170830，2022.01-2025.12，58万，58万，在研，主持。 5.国家自然科学基金青年项目，81700150，在斑马鱼中过表达人源性BCR/ABL1导致白血病的机制研究及模型建立，2018.01-2020.12，20万，结题，主持。 6.广东省自然科学基金，cmyb-lect2l通路在骨髓增生综合症中的机制研究, 2021A1515010422，2021.01-2023.12，10万，结题，主持。 7.广东省自然科学基金,基于药物筛选的斑马鱼runx1突变体白血病模型的建立及机制研究, 2016A030310378，2016.07-2018.7，10万，结题，主持。 8.中国博士后科学基金一等资助, 2016M600660，可供药物筛选的FPD/AML斑马鱼模型的建立及机制研究， 2017.01-2018.12，8万，结题，主持。 9.中央高校基本科研业务费，2019MS130，表观修饰因子cbx4在造血调控中的机制研究，2019.01-2020.12，10万，10万，结题，主持。 10.中央高校基本科研业务费，2022ZYGXZR031，非甾体抗炎药舒林酸及塞来昔布选择性诱导γ-氨基丁酸能神经元死亡的机制研究，2022.01-2023.12，10万，结题，主持。
论文
- Sun, Wenwei;Wang, Meimei;Zhao, Jun;Zhao, Shuang;Zhu, Wenchao;Wu, Xiaoting;Li, Feifei;Liu, Wei;Wang, Zhuo;Gao, Meng;Zhang, Yiyue;Xu, Jin;Zhang, Meijia;Wang, Qiang;Wen, Zilong;Shen, Juan;Zhang, Wenqing;Huang, Zhibin,Sulindac selectively induces autophagic apoptosis of GABAergic neurons and alters motor behaviour in zebrafish,Nature Communications,14
- Chen, Kemin;Wu, Jieyi;Zhang, Yuxian;Liu, Wei;Chen, Xiaohui;Zhang, Wenqing;Huang, Zhibin,Cebpa is required for haematopoietic stem and progenitor cell generation and maintenance in zebrafish,Open Biology,14
- Huang, Zhenhan;Yang, Xiaojun;Qin, Xun;Chen, Kemin;Liu, Wei;Xu, Jin;Li, Jianchao;Zhang, Wenqing;Huang, Zhibin,Localized production of LECT2 by orthotopic histiocytes during inflammation,Journal of Genetics and Genomics,51
- Ye Yin;Yang Xiaojun;Li Feifei;Liu Wei;Zhang Wenqing;Huang Zhibin,c-myb is involved in CML progression and is a therapeutic target in the zebrafish CML model,Animal Models and Experimental Medicine,7
- 杨晓君;黄振瀚;刘伟;张文清;黄志斌,CD209同源基因在斑马鱼中的鉴定及功能表征,遗传,46
- Chen, Qi;Kou, Hanjing;Demy, Doris Lou;Liu, Wei;Li, Jianchao;Wen, Zilong;Herbomel, Philippe;Huang, Zhibin;Zhang, Wenqing;Xu, Jin,The different roles of V-ATPase a subunits in phagocytosis/endocytosis and autophagy,Autophagy,20
- 陈克敏;黄志斌;王顺清;张文清,CEBPA bZIP框内突变在急性髓系白血病中的研究进展,广州医药,56
- Luo, Haiping;Li, Qiqi;Hong, Jiaxin;Huang, Zhibin;Deng, Wenhui;Wei, Kunpeng;Lu, Siyu;Wang, Hailong;Zhang, Wenqing;Liu, Wei,Targeting TNF/IL-17/MAPK pathway in hE2A-PBX1 leukemia: effects of OUL35, KJ-Pyr-9, and CID44216842,Haematologica
- Li, Gaofei;Sun, Yicong;Kwok, Immanuel;Yang, Liting;Wen, Wanying;Huang, Peixian;Wu, Mei;Li, Jing;Huang, Zhibin;Liu, Zhaoyuan;He, Shuai;Peng, Wan;Bei, Jin-Xin;Ginhoux, Florent;Ng, Lai Guan;Zhang, Yiyue,Cebp1 and Cebpβ transcriptional axis controls eosinophilopoiesis in zebrafish,Nature communications,1
- Zhang, Ao;Lu, Jingao;Feng, Shachuan;Yu, Huapeng;Yu, Tao;Zhao, Shizheng;Chen, Kemin;Huang, Zhibin;Xu, Jin;Qu, Jianan Y.;Wen, Zilong,Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish,Journal of Genetics and Genomics,51
- Li, Gaofei;Sun, Yicong;Kwok, Immanuel;Yang, Liting;Wen, Wanying;Huang, Peixian;Wu, Mei;Li, Jing;Huang, Zhibin;Liu, Zhaoyuan;He, Shuai;Peng, Wan;Bei, Jin-Xin;Ginhoux, Florent;Ng, Lai Guan;Zhang, Yiyue,Cebp1 and Cebpβ transcriptional axis controls eosinophilopoiesis in zebrafish,Nature Communications,15
- Zhao, Shuang;Mo, Guiling;Wang, Qiang;Xu, Jin;Yu, Shihui;Huang, Zhibin;Liu, Wei;Zhang, Wenqing,Role of RB1 in neurodegenerative diseases: inhibition of post-mitotic neuronal apoptosis via Kmt5b,Cell Death Discovery,10
- Luo, Haiping;Li, Qiqi;Hong, Jiaxin;Huang, Zhibin;Deng, Wenhui;Wei, Kunpeng;Lu, Siyu;Wang, Hailong;Zhang, Wenqing;Liu, Wei,Targeting TNF/IL-17/MAPK pathway in hE2A-PBX1 leukemia: effects of OUL35, KJ-Pyr-9, and CID44216842,Haematologica-The Hematology Journal,109
- Zhao, Shuang;Wang, Chen;Luo, Haiping;Li, Feifei;Wang, Qiang;Xu, Jin;Huang, Zhibin;Liu, Wei;Zhang, Wenqing,A role for Retinoblastoma 1 in hindbrain morphogenesis by regulating GBX family,Journal of Genetics and Genomics,51
- Zhao, Zibo;Lin, Shimin;Liu, Tao;Hu, Xiao;Qin, Shurong;Zhan, Fengyun;Ma, Jiaqi;Huang, Chen;Huang, Zhibin;Wang, Yifei;Zheng, Kai;Zhang, Wenqing;Ren, Zhe,Artemvulactone E isolated from Artemisia vulgaris L. ameliorates lipopolysaccharide-induced inflammation in both RAW264.7 and zebrafish model,Frontiers in Pharmacology,15
- 黄志斌,Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish,Journal of genetics and genomics
- Li Xuexiao;Wang Luping;Qin Xun;Chen Xiaohui;Li Li;Huang Zhibin;Zhang Wenqing;Liu Wei,Estrogens revert neutrophil hyperplasia by inhibiting Hif1α-cMyb pathway in zebrafish myelodysplastic syndromes models.,Cell death discovery,8
- Lu Jing'ao;Huang Chun-Yan;Lin Zhi-Yin;Tang Zheng;Ma Ning;Huang Zhi-Bin,The role of the cd99l2 gene on leukocyte interstitial migration in zebrafish,Yi chuan = Hereditas,44
- Dai, Wencong;Wang, Kunyuan;Zhen, Xinchun;Huang, Zhibin;Liu, Li,Magnesium isoglycyrrhizinate attenuates acute alcohol-induced hepatic steatosis in a zebrafish model by regulating lipid metabolism and ER stress,Nutrition & Metabolism,19
- 卢荆澳;黄春燕;林芷茵;唐政;马宁;黄志斌,cd99l2基因调控斑马鱼白细胞组织间的迁移机制,遗传,44
- Ye Yin;Yang Xiaojun;Li Feifei;Liu Wei;Zhang Wenqing;Huang Zhibin,c-myb is involved in CML progression and is a therapeutic target in the zebrafish CML model.,Animal models and experimental medicine
- Huang Zhibin;Chen Kemin;Chi Yali;Jin Hao;Li Li;Zhang Wenqing;Xu Jin;Zhang Yiyue,Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb,Journal of Biological Chemistry,296
- Zhao, Yan;Wu, Mei;Li, Jing;Meng, Ping;Chen, Jiakui;Huang, Zhibin;Xu, Jin;Wen, Zilong;Zhang, Wenqing;Zhang, Yiyue,The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway,Cell Death & Disease,12
- Fang, Xiao;Xu, Song'en;Zhang, Yiyue;Xu, Jin;Huang, Zhibin;Liu, Wei;Wang, Shunqing;Yen, Kuangyu;Zhang, Wenqing,Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish,Leukemia,35
- Chen, Jiakui;Li, Gaofei;Lian, Junwei;Ma, Ning;Huang, Zhibin;Li, Jianchao;Wen, Zilong;Zhang, Wenqing;Zhang, Yiyue,Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish,Science China Life Sciences,64
- Huang Zhibin;Chen Kemin;Chi Yali;Jin Hao;Li Li;Zhang Wenqing;Xu Jin;Zhang Yiyue,Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb,Journal of Biological Chemistry,296
- Zhao Yan;Wu Mei;Li Jing;Meng Ping;Chen Jiakui;Huang Zhibin;Xu Jin;Wen Zilong;Zhang Wenqing;Zhang Yiyue,The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway.,Cell death & disease,12
- Liu Wei;Di Qianqian;Li Kailun;Li Jing;Ma Ning;Huang Zhibin;Chen Jiahao;Zhang Sheng;Zhang Wenqing;Zhang Yiyue,The synergistic role of Pu.1 and Fms in zebrafish osteoclast-reducing osteopetrosis and possible therapeutic strategies,Journal of Genetics and Genomics,47
- Xu, Mengchang;Ye, Yin;Ye, Zhi'an;Xu, Song'en;Liu, Wei;Xu, Jin;Zhang, Yiyue;Liu, Qifa;Huang, Zhibin;Zhang, Wenqing,Human BCR/ABL1 induces chronic myeloid leukemia-like disease in zebrafish,Haematologica-The Hematology Journal,105
- Wang, Tienan;Yan, Bo;Lou, Liang;Lin, Xi;Yu, Tao;Wu, Shuting;Lu, Qing;Liu, Wei;Huang, Zhibin;Zhang, Mingjie;Zhang, Wenqing;Wen, Zilong,Nlrc3-like is required for microglia maintenance in zebrafish,Journal of Genetics and Genomics,46
- Jin, Wan;Dai, Yimei;Li, Funing;Zhu, Lu;Huang, Zhibin;Liu, Wei;Li, Jianchao;Zhang, Mingjie;Du, Jiulin;Zhang, Wenqing;Wen, Zilong,Dysregulation of Microglial Function Contributes to Neuronal Impairment in Mcoln1a-Deficient Zebrafish,iScience,13
- Chi, Yali;Huang, Zhibin;Chen, Qi;Xiong, Xiaojie;Chen, Kemin;Xu, Jin;Zhang, Yiyue;Zhang, Wenqing,Loss of runx1 function results in B cell immunodeficiency but not T cell in adult zebrafish,Open Biology,7
- Zhang, Zili;Liu, Wei;Zhao, Lingfeng;Huang, Zhibin;Chen, Xiaohui;Ma, Ning;Xu, Jin;Zhang, Wenqing;Zhang, Yiyue,Retinoblastoma 1 protects T cell maturation from premature apoptosis by inhibiting E2F1,Development,145
- Liu, W;Wu, M;Huang, Z;Lian, J;Chen, J;Wang, T;Leung, A Y H;Liao, Y;Zhang, Z;Liu, Q;Yen, K;Lin, S;Zon, Li;Wen, Z;Zhang, Y;Zhang, W,c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish,leukemia,31
- 黄志斌,Cebpa is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish,JOURNAL OF GENETICS AND GENOMICS,43
- Jin, Hao;Huang, Zhibin;Chi, Yali;Wu, Mei;Zhou, Riyang;Zhao, Lingfeng;Xu, Jin;Zhen, Fenghua;Lan, Yahui;Li, Li;Zhang, Wenqing;Wen, Zilong;Zhang, Yiyue,c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish,BLOOD,128
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