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Lijianchao

ProfessorDoctoral Supervisor,

Tel:

Email: lijch@scut.edu.cn

Department: School of Medicine

Office Location: B2-511

Research Interests:

  • Biography
  • Education
  • Admission Information
  • Work Experience
  • Social Position
  • Research Areas
  • Courses Taught
  • Research Project
  • Selected Publications
  • Achievements
  • Patent
  • Honor
  • Software achievement

Biography

The research group employs biochemical, structural, and cell biological approaches to study protein complexes linked to hereditary diseases, aiming to provide mechanistic insights for treating ciliopathies, hereditary deafness, and neurological disorders. Our current research focuses on the molecular assembly of cell protrusions, such as stereocilia, microvilli, and cilia.

With over 40 SCI publications, the group has authored significant studies in leading journals including Nat Chem Biol, Nat Struct Mol Biol, Nat Commun, Dev Cell, Cell Rep, PNAS, and eLife. The lab’s research is funded by the National Natural Science Foundation of China and the Fundamental Research Funds for the Central Universities.


Education

2012-2015, Hong Kong University of Science and Technology, Ph.D degree in Life Science

2010-2012, Hong Kong University of Science and Technology, MPhil degree in Biochemistry

2006-2010, Nanjing University, Bachelor degree in Chemistry


Admission Information

WorkExperience

Social Position

Research Areas

Research Overview

By integrating biochemical, structural biological, and cell biological approaches, our group investigates the functions of protein molecules and their complexes associated with hereditary diseases. Our work aims to provide a theoretical foundation for the understanding and potential treatment of genetic disorders, such as hereditary deafness and neurological conditions.

Our current research focuses on:

  1. Molecular mechanisms of cell protrusion assembly: Investigating how stereocilia, microvilli, and cilia are constructed and maintained.

  2. Myosin regulation and transport: Exploring the calcium-dependent regulatory mechanisms and cargo recognition of myosins within stereocilia and microvilli.

  3. Ankyrin-mediated protein complexes: Studying the formation mechanisms and physiological functions of ankyrin-mediated complexes at the Axon Initial Segment (AIS).


Courses Taught

Medical Cell Biology

Biochemistry and Molecular Biology


Research Project

Selected Publications

  • Liu, Jia; Wu, Cang; Liu, Yuyang; Chen, Qiangou; Ding, Yuzhen Ding; Lin, Zhiqiao; Pan, Lifeng; Xiao, Kang; Li, Jianchao; Liu, Zhongmin; Liu, Wei,Structural insights into the dual Ca2+-sensor-mediated activation of the PPEF phosphatase family,Nature Communications,20250401
  • Xu, Xiaohan;Ren, Jing;Li, Jianchao,Dimerization of the BAR domain-containing protein FAM92A modulates lipid binding and interaction with CBY1,JOURNAL OF BIOLOGICAL CHEMISTRY,2025
  • Wang, Jing-Xin;Li, Zhi-Wei;Liu, Wei;Zhang, Wen-Qing;Li, Jian-Chao,Junctophilin-2 MORN-Helix Domain: Structural Basis for Membrane Binding and Hypertrophic Cardiomyopathy-associated Mutations,Progress in Biochemistry and Biophysics,2025
  • He, Ran;Chen, Guanhao;Li, Zhiwei;Li, Jianchao,Structure of the N-terminal coiled-coil domains of the ciliary protein Rpgrip1l,iScience,2023
  • Li, Jianchao*,Liquid-liquid phase separation in hair cell stereocilia development and maintenance,Computational and Structural Biotechnology Journal,2023
  • Ding, Yuzhen;Chen, Qiangou;Shan, Hui;Liu, Jia;Lv, Chunyu;Wang, Yanhui;Yuan, Lin;Chen, Yu;Wang, Ziyi;Yin, Yuxin;Xiao, Kang;Li, Jianchao;Liu, Wei,SASH1: A Novel Eph Receptor Partner and Insights into SAM-SAM Interactions,Journal of Molecular Biology,2023
  • Yan, Wenxia;Chen, Guanhao;Li, Jianchao*,Structure of the Harmonin PDZ2 and coiled-coil domains in a complex with CDHR2 tail and its implications,The FASEB Journal,2022
  • He, Liping;Jiang, Wenli;Li, Jianchao;Wang, Chao,Crystal structure of Ankyrin-G in complex with a fragment of Neurofascin reveals binding mechanisms required for integrity of the axon initial segment,JOURNAL OF BIOLOGICAL CHEMISTRY,2022
  • Zhao, Junfeng;Li, Zhiwei;Li, Jianchao,The crystal structure of the FAM134B-GABARAP complex provides mechanistic insights into the selective binding of FAM134 to the GABARAP subfamily,FEBS Open Bio,2022
  • Ye, Jin;Zou, Guichang;Zhu, Ruichi;Kong, Chao;Miao, Chenjian;Zhang, Mingjie;Li, Jianchao;Xiong, Wei;Wang, Chao,Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission,Nature Communications,2021
  • Li, Jianchao;Chen, Keyu;Zhu, Ruichi;Zhang, Mingjie,Structural Basis Underlying Strong Interactions between Ankyrins and Spectrins,Journal of Molecular Biology,2020
  • Li Jianchao;Zhang Mingjie,Cargo Binding by Unconventional Myosins.,Advances in experimental medicine and biology,2020
  • Ye, Jin;Li, Jianchao;Ye, Fei;Zhang, Yan;Zhang, Mingjie;Wang, Chao,Mechanistic insights into the interactions of dynein regulator Ndel1 with neuronal ankyrins and implications in polarity maintenance,Proceedings of the National Academy of Sciences,2020
  • Li, Jianchao;Liu, Haiyang;Raval, Manmeet H.;Wan, Jun;Yengo, Christopher M.;Liu, Wei;Zhang, Mingjie,Structure of the MORN4/Myo3a Tail Complex Reveals MORN Repeats as Protein Binding Modules,Structure,2019
  • He, Yunyun;Li, Jianchao;Zhang, Mingjie,Myosin VII, USH1C, and ANKS4B or USH1G Together Form Condensed Molecular Assembly via Liquid-Liquid Phase Separation,Cell Reports,2019
  • Liu, Haiyang;Li, Zhiwei;Yang, Qingqing;Liu, Wei;Wan, Jun;Li, Jianchao;Zhang, Mingjie,Substrate docking-mediated specific and efficient lysine methylation by the SET domain-containing histone methyltransferase SETD7,JOURNAL OF BIOLOGICAL CHEMISTRY,2019

Achievements

Patent

Honor

Software achievement