Education
2002-2008 Ph.D. National University of Singapore, Institute of Molecular and Cell Biology
WorkExperience
2008-2017 Research Assistant/Research Associate Hong Kong University of Science and Technology 2017-now Professor South China University of Technology
Research
Our laboratory is dedicated to studying the composition, development, and functions of both traditional and non-traditional clearance systems in the body. We primarily leverage the unique advantages of the zebrafish model to conduct studies that are difficult or impossible to perform in mice, with the goal of filling gaps in existing research frameworks. Zebrafish embryos are produced in large numbers and are transparent, making them an excellent model for forward genetic screening, real-time in vivo imaging, and optical microsurgery. By observing the behavior and roles of clearance-related cells in real time during zebrafish development, we aim to gain a clearer understanding of the interactions between these cells and other tissue cells. Additionally, by designing appropriate forward genetic screens, we can uncover the roles of previously unknown genes in novel biological processes. Our laboratory strives to conduct innovative research by capitalizing on the unique advantages of the zebrafish model. Current research focuses include: Investigating new functions of scavenger endothelial cells. Studying the development and function of classical innate immune cells.
Open Course
Biochemistry and Molecular Biology, Cell Biology
Research Project
National key R&D Program of China, the National Natural Science Foundation of China, National Natural Science Foundation of China (NSFC)/Research Grants Council (RGC) Joint Research Scheme, Guangdong Basic and Applied Basic Research Foundation, Guangdong Science and Technology Plan Projects
Thesis
- Dai, Yimei;Jiang, Yunyun;Cao, Canran;Xu, Yongtai;Lai, Siting;Zhu, Wenchao;Gao, Meng;Li, Feifei;He, Sicong;Xu, Jin,Scavenger endothelial cells alleviate tissue damage by engulfing toxic molecules derived from hemolysis,Proceedings of the National Academy of Sciences,122
- Chen, Jiahao;Wang, Honggao;Wu, Shuting;Zhang, Ao;Qiu, Zhongkai;Huang, Peng;Qu, Jianan Y.;Xu, Jin,col1a2+ fibroblasts/muscle progenitors finetune xanthophore countershading by differentially expressing csf1a/1b in embryonic zebrafish,Science Advances,10
- Yu, Tao;Chen, Jiahao;Wang, Yuexin;Xu, Jin,The embryonic zebrafish brain is exclusively colonized by pu.1-dependent and lymphatic-independent population of microglia,Science Advances,10
- Dai, Yimei;Wu, Shuting;Cao, Canran;Xue, Rongtao;Luo, Xuefen;Wen, Zilong;Xu, Jin,Csf1rb regulates definitive hematopoiesis in zebrafish,Development,149
- Chen, Qi;Kou, Hanjing;Demy, Doris Lou;Liu, Wei;Li, Jianchao;Wen, Zilong;Herbomel, Philippe;Huang, Zhibin;Zhang, Wenqing;Xu, Jin,The different roles of V-ATPase a subunits in phagocytosis/endocytosis and autophagy,Autophagy,20
- He, Sicong;Tian, Ye;Feng, Shachuan;Wu, Yi;Shen, Xinwei;Chen, Kani;He, Yingzhu;Sun, Qiqi;Li, Xuesong;Xu, Jin;Wen, Zilong;Qu, Jianan Y.,In vivo single-cell lineage tracing in zebrafish using high-resolution infrared laser-mediated gene induction microscopy,eLife,9
- He, Sicong;Chen, Jiahao;Jiang, Yunyun;Wu, Yi;Zhu, Lu;Jin, Wan;Zhao, Changlong;Yu, Tao;Wang, Tienan;Wu, Shuting;Lin, Xi;Qu, Jianan Y.;Wen, Zilong;Zhang, Wenqing;Xu, Jin,Adult zebrafish Langerhans cells arise from hematopoietic stem/progenitor cells,eLife,7
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