Zhangmeijia

2002-09-2005-06, China Agricultural University, Physiology, Doctor

1994-09-1997-06, Northwest Agricultural University, Veterinary Obstetrics, Master's Degree

1989-08-1994-06, Northwest Agricultural University, Veterinary Medicine, Bachelor's Degree

Since November 2019, South China University of Technology, Reproductive Physiology and Development

July 2009 - September 2010, Jackson Laboratory, USA, oocyte meiosis arrest

July 20, 2005, 19-10, China Agricultural University, Reproductive Biology Research

October 2000 - June 2001, Kyushu University, Japan, Oocyte cryopreservation research

July 20, 1997, 02-08, Chengdu Research Base of Giant Panda Breeding, Research on Giant Panda breeding

Associate Editor of Journal of Ovarian Research

Associate Editor of Animal Models and Experimental Medicine

Director of the Reproductive Biology Branch of the Zoological Society of China

Mainly engaged in research related to reproductive physiology and development. Relying on the scientific research platform of the Innovation Center for Basic Research on Development and Disease Medicine of the Ministry of Education, in collaboration with the Reproductive Center of the affiliated clinical hospital, a series of scientific studies have been carried out using the conditional gene knockout mouse model, mainly including:

1) The molecular mechanism of primordial follicle activation

2) Molecular regulation of follicular development and maturation

3) The important role of histone modification in maintaining the gonads of adult mammals;

4) The role of palmitoylation modification in sperm maturation.

These research works will lay the foundation for clinical applications such as in vivo fertility protection for patients with early-onset ovarian insufficiency (POI) and chemotherapy patients in clinical practice.

Undergraduate course: Physiology

Master's Degree program: Advances in Physiology and Medicine

Doctoral Program: Advances in Physiology and Pathology Research

1. Research on the Initiation Regulatory Factors of Primordial Follicle Activation and the Screening and clinical Application of Targeted Oral Drugs, Key Project of the National Natural Science Foundation of China Regional Innovation Development Joint Fund, 2025-2028, Project Leader;

2. The Role and Mechanism of Myelocytoma Virus Oncogene MYC in Follicular Development and Maturation, National Natural Science Foundation of China General Program, 2023-2026, Project Leader;

3. Research on Key Mechanisms of Freezing and thawing of Germ Cells and gonadal Tissues and Development and application of New Functional Repair Technologies, Key Special Project of Reproductive Health and Women and Children's Health Security of the Ministry of Science and Technology, Sub-project leader, 2022-2025

4. The Role and Molecular Mechanism of CXXC zinc Finger Protein 1 (CFP1) in Follicular Development in Granulosa Cells, National Natural Science Foundation of China General Program, 2020-2023, Project Leader;

5. Research on the Role and Mechanism of Follicular Microenvironment and Ovarian Lesions in Affecting Oocyte Development and Maturation, Key Special Project of the Key Research and Development Program of the Ministry of Science and Technology, 2018-2021, Project Leader;

6. Oocyte Meiosis, National Science Fund for Distinguished Young Scholars, 2015-2019, Project Leader;

7. Molecular Mechanism of Elevated Calcium Ion Levels in Cumulus Cells by LH-EGFR Signaling, General Project of National Natural Science Foundation of China, 2018-2021, Project Leader;

8. Research on the Mechanism of Human Fertility Decline and New Strategies for Protection and Preservation, Key Research and Development Project of the Ministry of Science and Technology, 2017-2020, Sub-project Leader;

9. Molecular Mechanisms Determining Oocyte Quality, National Major Scientific Research Program of the Ministry of Science and Technology, 2014-2018, Sub-Project Leader;

10. Molecular Mechanism of Gonadotropin Regulation of C-type Natriuretic Peptide and Its Receptor Expression, General Project of National Natural Science Foundation of China, 2013-2016, Project Leader;

11. Molecular Basis of Meiosis in Female Germ Cells, National Key Basic Research Program of the Ministry of Science and Technology, 2012-2016, Project Leader;

12. Expression Regulation Mechanism of NPR2 receptor, Ministry of Education's New Century Excellent Talent Support Program, 2011-2013, Project Leader;

13. Expression Changes of cardiac natriuretic peptide in Fallopian tubes and Its role and mechanism in fertilization, National Natural Science Foundation of China General Project, 2007-2009, Project Leader;