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Ruanzhi

ProfessorSupervisor of Master and Doctoral Candidates,

Tel:

Email: zhiruan@scut.edu.cn

Department: School of Food Science and Engineering

Office Location:

Research Interests: Nutrition and Brain Health

Biography

Education

Education and Training

2017-2021 Postdoctoral Associate, Neuroscience, Boston University, Boston, MA, USA

2015-2017 Postdoctoral Fellow, Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA

2010-2015 Ph.D., Pharmacology, Chinese Academy of Sciences, Shanghai, China

2006-2010 B.S., Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China


Admission Information

WorkExperience

Social Position

Research Areas

We primarily focus on the molecular basis underlying the functional decline of brain cells during aging. By integrating research strategies such as genetic sequencing, proteomics, nutrient identification, and brain cell functional analysis, we conduct in-depth interdisciplinary research centered on the nutritional requirements for healthy brain cells and the development of functional foods. Our goal is to provide precise interventions and nutritional strategies to enhance brain cell function and protect brain health. Additionally, we are also interested in the mechanisms by which microglia maintain homeostasis in the central nervous system, as well as the precise nutritional value of stem cell-derived exosomes.

Courses Taught

Cellular and Molecular Biology


Research Project

Selected Publications

  • Victor Bodart-Santos,Selenoprotein P is a target for regulating extracellular vesicle biogenesis and secretion from activated microglia in vivo,Cell Reports,2024
  • Zhi Ruan,Functional genome-wide short-hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia,Cell reports,2022
  • Zhi Ruan,Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons,Brain,2021
  • Zhi Ruan,MIF promotes neurodegeneration and cell death via its nuclease activity following traumatic brain injury,Cellular and Molecular Life Sciences,2021
  • Zhi Ruan,P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice,Molecular neurodegeneration,2020

Achievements

Patent

Honor

Software achievement