Biography
Education
Admission Information
Work Experience
Social Position
Research Areas
Courses Taught
Research Project
Selected Publications
- Hantao Luo, Yuhui Du, Leping Sun, Fangkai Ye, Jiezhao Ma, Xueting Wang, Yaxin Wang, Tingjian Chen,Recognition of unnatural base pairs by a eukaryotic DNA polymerase enables universal sequencing of an expanded genetic alphabet,Nucleic Acids Research,2026
- Zhang, Binliang;Du, Yuhui;Zhang, Jingxing;Ma, Xingyun;Qin, Yanjia;Tao, Rui;Luo, Minglan;Wu, Jing;Sun, Leping;Zhu, Gan;Luo, Hantao;Wen, Junlin;Xiong, Chenghe;Mei, Hui;Chen, Tingjian,A solid-phase enzymatic synthesis platform for the facile production of 2′-fluoroarabinonucleic acid (FANA) and chimeric XNA oligonucleotides using an evolved XNA polymerase,Nucleic Acids Research,2025
- Peng, Leli;Ye, Fangkai;Zhang, Ruimin;Du, Yuhui;Liu, Qiaoling;Zhang, Rujie;Zhang, Binliang;Chen, Tingjian,Rolling Circle Amplification with an Expanded Genetic Alphabet (ExRCA) Generates DNA Materials Incorporating Additional Building Blocks for Enhanced Programmable Functionalization,Journal of the American Chemical Society,2025
- Li, Xiaofeng;Shan, Xi;Chen, Jiadong;Zhu, Jun;Chen, Yang;Chen, Xueyi;Li, Shahao;Lu, Mengze;Du, Yuhui;Yin, Panchao;Chen, Tingjian;Sun, Taolin,Bioinspired DNA Plastics with Brick-and-Mortar Structure: Enhanced Toughness, Recyclability, and Degradability,Chem and Bio Engineering,2025
- Wu, Jing;Xiao, Ziqian;Du, Yuhui;Luo, Minglan;Zhang, Jiacheng;Guo, Pei;Chen, Zhipeng;Yang, Binyuan;Chen, Tingjian,Generation of Stable 2'-F/OMe-RNA Aptasensors for Bacillus cereus 5/B/6 Metallo-β-Lactamase,ACS Synthetic Biology,2025
- Du, Yuhui;Zheng, Xinqian;Ma, Yuan;Ge, Fangjun;Li, Qiuyan;Xiang, Hao;Chen, Xueyi;Zhou, Hai;Sun, Taolin;Chen, Tingjian,Preparation of Biomass-Derived DNA-Chitosan Polyelectrolyte Complex Hydrogels for Economical and Reliable DNA Preservation and Protein Immobilization,ACS Sustainable Chemistry and Engineering,2024
- Sun, Leping;Xiang, Yuming;Du, Yuhui;Wang, Yangming;Ma, Jiezhao;Wang, Yaxin;Wang, Xueting;Wang, Guangyuan;Chen, Tingjian,Template-independent synthesis and 3′-end labelling of 2′-modified oligonucleotides with terminal deoxynucleotidyl transferases,Nucleic Acids Research,2024
- Du, Yuhui;Qian, Chengqian;Li, Xianxin;Zheng, Xinqian;Huang, Shoucong;Yin, Zhiqiu*;Chen, Tingjian*;Pan, Li*,Unveiling intraspecific diversity and evolutionary dynamics of the foodborne pathogen Bacillus paranthracis s through high-quality pan-genome analysis,Current Research in Food Science,2024
- Wen, Chongzheng;Wang, Guangyuan;Yang, Lin;Chen, Tingjian;Liu, Haiping;Gong, Weimin,Structural Basis for C2'-methoxy Recognition by DNA Polymerases and Function Improvement,Journal of Molecular Biology,2024
- Guangyuan Wang, Yuhui Du, Tingjian Chen,Enzymatic Preparation of DNA with an Expanded Genetic Alphabet Using Terminal Deoxynucleotidyl Transferase and Its Applications,Synthetic Biology: Methods and Protocols,2024
- Du, Yuhui;Zou, Jinrong;Yin, Zhiqiu;Chen, Tingjian,Pan-Chromosome and Comparative Analysis of Agrobacterium fabrum Reveal Important Traits Concerning the Genetic Diversity, Evolutionary Dynamics, and Niche Adaptation of the Species,Microbiology Spectrum,2023
- Cao, Yijun;Bai, Jingsi;Zou, Jinrong;Du, Yuhui;Chen, Tingjian,One-Pot Enzymatic Preparation of Oligonucleotides with an Expanded Genetic Alphabet via Controlled Pause and Restart of Primer Extension: Making Unnatural Out of Natural,ACS Synthetic Biology,2023
- Qin, Yanjia;Ma, Xingyun;Tao, Rui;Du, Yuhui;Chen, Tingjian,Synthesis, Reverse Transcription, Replication, and Inter-Transcription of 2'-Modified Nucleic Acids with Evolved Thermophilic Polymerases: Efforts toward Multidimensional Expansion of the Central Dogma,ACS Synthetic Biology,2023
- Bai, Jingsi;Zou, Jinrong;Cao, Yijun;Du, Yuhui;Chen, Tingjian,Recognition of an Unnatural Base Pair by Tool Enzymes from Bacteriophages and Its Application in the Enzymatic Preparation of DNA with an Expanded Genetic Alphabet,ACS Synthetic Biology,2023
- Chen, Xueyi;Zhang, Rujie;Peng, Leli;Du, Yuhui;Chen, Tingjian,Bottlebrush DNA-Primed Rolling Circle Amplification for Sensitive Detection of Biomolecules,ACS Applied Nano Materials,2023
- Guo, Yuan-Yang;Zhang, Rujie;Huo, Bianbian;Wang, Luying;Yuan, Donghe;Bai, Jingsi;Wang, Honglei;Zhu, Gongming;Zhang, Xiguang;Zhu, Anlian;Chen, Tingjian;Li, Lingjun,Site-specific unnatural base excision via visible light,Chemical communications,2022
- Lu, Mengze;Liu, Fei;Tan, Rui;Xiao, Zhenhua;Dong, Xue-hui;Wang, Hui;Tang, Liqun;Chen, Tingjian;Wu, Zi Liang;Hong, Wei;Sun, Taolin,Phase-Separation-Induced Porous Hydrogels from Amphiphilic Triblock Copolymer with High Permeability and Mechanical Strength,Chemistry of Materials,2022
- Zhu, Gan;Song, Ping;Wu, Jing;Luo, Minglan;Chen, Zhipeng;Chen, Tingjian,Application of Nucleic Acid Frameworks in the Construction of Nanostructures and Cascade Biocatalysts: Recent Progress and Perspective,Frontiers in Bioengineering and Biotechnology,2022
- Wang, Guangyuan;He, Chuanping;Zou, Jinrong;Liu, Jiayun;Du, Yuhui;Chen, Tingjian,Enzymatic Synthesis of DNA with an Expanded Genetic Alphabet Using Terminal Deoxynucleotidyl Transferase,ACS Synthetic Biology,2022
- Wang Guangyuan;Du Yuhui;Ma Xingyun;Ye Fangkai;Qin Yanjia;Wang Yangming;Xiang Yuming;Tao Rui;Chen Tingjian,Thermophilic Nucleic Acid Polymerases and Their Application in Xenobiology,International Journal of Molecular Sciences,2022
- Sun Leping;Ma Xingyun;Zhang Binliang;Qin Yanjia;Ma Jiezhao;Du Yuhui;Chen Tingjian,From polymerase engineering to semi-synthetic life: artificial expansion of the central dogma,RSC Chemical Biology,2022
- Song Ping;Zhang Rujie;He Chuanping;Chen Tingjian,Transcription, Reverse Transcription, and Amplification of Backbone-Modified Nucleic Acids with Laboratory-Evolved Thermophilic DNA Polymerases.,Current protocols,2021
- Qian Shao, Tingjian Chen, Kai Sheng, Zhixia Liu, Zhuochen Zhang, Floyd E Romesberg,Selection of aptamers with large hydrophobic 2′-substituents,Journal of the American Chemical Society,2020
- Deepak Thirunavukarasu, Tingjian Chen, Zhixia Liu, Narupat Hongdilokkul, Floyd E Romesberg,Selection of 2′-fluoro-modified aptamers with optimized properties,Journal of the American Chemical Society,2017
- Zhixia Liu, Tingjian Chen, Floyd E Romesberg,Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers,Chemical Science,2017
- Tingjian Chen, Floyd E Romesberg,Enzymatic synthesis, amplification, and application of DNA with a functionalized backbone,Angewandte Chemie International Edition,2017
- Tingjian Chen, Floyd E Romesberg,Polymerase chain transcription: exponential synthesis of RNA and modified RNA,Journal of the American Chemical Society,2017
- Tingjian Chen, Floyd E Romesberg,A method for the exponential synthesis of RNA: introducing the polymerase chain transcription (PCT) reaction,Biochemistry,2017
- Tingjian Chen, Narupat Hongdilokkul, Zhixia Liu, Ramkrishna Adhikary, Shujian S Tsuen, Floyd E Romesberg,Evolution of thermophilic DNA polymerases for the recognition and amplification of C2ʹ-modified DNA,Nature chemistry,2016
- Tingjian Chen, Narupat Hongdilokkul, Zhixia Liu, Deepak Thirunavukarasu, Floyd E Romesberg,The expanding world of DNA and RNA,Current opinion in chemical biology,2016
- Ramkrishna Adhikary, Wayne Yu, Masayuki Oda, Ross C Walker, Tingjian Chen, Robyn L Stanfield, Ian A Wilson, Jörg Zimmermann, Floyd E Romesberg,Adaptive mutations alter antibody structure and dynamics during affinity maturation,Biochemistry,2015
- Denis A Malyshev, Kirandeep Dhami, Thomas Lavergne, Tingjian Chen, Nan Dai, Jeremy M Foster, Ivan R Corrêa, Floyd E Romesberg,A semi-synthetic organism with an expanded genetic alphabet,Nature,2014
- Tingjian Chen, Floyd E Romesberg,Directed polymerase evolution,FEBS letters,2014
- Tingjian Chen, Jianqing Wang, Lingli Zeng, Rizong Li, Jicong Li, Yilu Chen, Zhanglin Lin,Significant rewiring of the transcriptome and proteome of an Escherichia coli strain harboring a tailored exogenous global regulator IrrE,PLoS One,2012
- Tingjian Chen, Jianqing Wang, Rong Yang, Jicong Li, Min Lin, Zhanglin Lin,Laboratory-evolved mutants of an exogenous global regulator, IrrE from Deinococcus radiodurans, enhance stress tolerances of Escherichia coli,PLoS One,2011
- Chuan Ren, Tingjian Chen, Jingqing Zhang, Ling Liang, Zhanglin Lin,An evolved xylose transporter from Zymomonas mobilis enhances sugar transport in Escherichia coli,Microbial cell factories,2009
- Tingjian Chen, Jingqing Zhang, Ling Liang, Rong Yang, Zhanglin Lin,An in vivo, label-free quick assay for xylose transport in Escherichia coli,Analytical biochemistry,2009
- Yong Chen, Shuang Li, Tingjian Chen, Hui Hua, Zhanglin Lin,Random dissection to select for protein split sites and its application in protein fragment complementation,Protein Science,2009
Achievements
Patent
Honor
Software achievement