个人简介
傅宏鑫，博士，主要从事梭菌细胞工厂创制与应用相关研究，包括梭菌遗传操作平台和基因组尺度代谢模型构建，利用合成生物学使能技术构建工农业废弃物（如木质纤维素、糖蜜、粗甘油、海洋生物质等）和二氧化碳利用梭菌底盘细胞、实现多种化学品（如丁酸、乳酸、丁醇、丁酸丁酯、1,3-丙二醇、γ-氨基丁酸等）的高效生产。承担和完成国家自然科学基金、广东省重点研发（子课题）、广东省自然科学基金、广州市应用基础研究计划等科研项目10项。在Chemical Engineering Journal、Metabolic Engineering、Biotechnology and Bioengineering、Separation and Purification Technology和Bioresource Technology等期刊发表SCI论文58篇，授权发明专利10项。目前担任Discover Applied Sciences和Frontiers in Chemical Engineering编委，以及30余种SCI期刊的审稿人。
教育经历
2009-09~2016-10,大连理工大学,生物化工,博士
2013-09~2015-10,俄亥俄州立大学，联合培养
招生信息
专业学位硕导,生物科学与工程学院,086000,生物与医药,生物工程
学术型硕导,生物科学与工程学院,071000,生物学,微生物学
学术型硕导,生物科学与工程学院,082200,发酵工程,发酵工程
工作经历
- 2020.9.1~至今,华南理工大学生物科学与工程学院
社会、学会及学术兼职
研究领域
(1) 代谢工程构建高效生产菌株
(2) 利用廉价原料发酵生产生物基化学品和生物燃料
(3) 发酵过程控制及优化
(4) 生物基化学品和生物燃料的下游分离工艺
开授课程
微生物学、文献检索与实践、生物技术综合实验、微生物制造新技术、基础生命科学
科研项目
主持
(1) 国家自然科学基金
(2) 广东省级科技计划项目（子课题 ）
(3) 广东省自然科学基金项目
(4) 广州市科技项目
(5) 博士后科学基金特别资助
(6) 博士后科学基金面上资助
(7) 中央高校基本科研业务费
参与
(1) 国家自然科学基金面上项目
(2) 广东省科技计划项目
(3) “863”计划子课题
(4) “年产千吨级生物基 1,3-丙二醇工业化示范”项目
论文
- Fu, Hongxin*;Li, Xin;Guo, Xiaolong;Yang, Die;Nan, Chenchen;Cheng, Jiale;Du, Haoming;Shen, Mengju;Wang, Jufang*,Consolidated bioprocessing of cassava starch into butyric acid and butanol by engineered Clostridium butyricum SCUT 620,Bioresource Technology,2025
- Mo, Yongzhang;Guo, Xiaolong;Lan, Yang;Wang, Jufang;Fu, Hongxin,Systems Metabolic Engineering of Clostridium tyrobutyricum for 1,3-Propanediol Production From Crude Glycerol,Biotechnology and Bioengineering,2025
- Guo, Xiaolong;Li, Xin;Feng, Jun;Yue, Zhi;Fu, Hongxin*;Wang, Jufang*;Guo Xiaolong;Li Xin;Feng Jun;Yue Zhi;Fu Hongxin*;Wang Jufang,Engineering of Clostridium tyrobutyricum for butyric acid and butyl butyrate production from cassava starch,Bioresource Technology,2024
- Fu, Hongxin*;Yang, Die;Li, Xin;Guo, Xiaolong;Mo, Yongzhang;Wang, Sheng;Wang, Jufang*,Metabolic and process engineering of Clostridium tyrobutyricum for efficient hydrogen production from sugarcane molasses,Fuel,2024
- Guo, Xiaolong;Ye, Fating;Nan, Chenchen;Cheng, Jiale;Feng, Jun;Fu, Hongxin*;Wang, Jufang,Efficient production of butyl butyrate from mannitol by engineered Clostridium tyrobutyricum,Chemical Engineering Journal,2024
- Guo, Xiaolong;Ding, Yuqing;Chen, Yufan;Fu, Hongxin*;Wang, Jufang*,Microbial cell factory for butyl butyrate production: Knowledges and perspectives,Microbial Biotechnology,2024
- Guo, Xiaolong;Ye, Fating;Nan, Chenchen;Cheng, Jiale;Feng, Jun;Fu, Hongxin*;Wang, Jufang,Efficient production of butyl butyrate from mannitol by engineered Clostridium tyrobutyricum,Chemical Engineering Journal,2024
- Dai, Kaiqun;Miao, Yuanhao;Qu, Chunyun;Wang, Cheng;Fu, Hongxin*;Wang, Jufang*,Adaptive laboratory evolution of Thermoanaerobacterium aotearoense for enhanced ethanol production from raw cassava starch,Renewable Energy,2024
- Guo Xiaolong;Zhang Huihui;Feng Jun;Yang Lu;Luo Kui;Fu Hongxin;Wang Jufang,De novo biosynthesis of butyl butyrate in engineered Clostridium tyrobutyricum,Metabolic Engineering,2023
- Fu, Hongxin;Yang, Lu;Zhang, Huihui;Wang, Jufang,Deciphering of the Mannitol Metabolism Pathway in Clostridium tyrobutyricum ATCC 25755 by Comparative Transcriptome Analysis,Applied Biochemistry and Biotechnology,2023
- Dai, Kaiqun;Qu, Chunyun;Feng, Jun;Lan, Yang;Fu, Hongxin*;Wang, Jufang*;Dai Kaiqun;Qu Chunyun;Feng Jun;Lan Yang;Fu Hongxin;Wang Jufang,Metabolic engineering of Thermoanaerobacterium aotearoense strain SCUT27 for biofuels production from sucrose and molasses,Biotechnology for Biofuels and Bioproducts,2023
- Guo Xiaolong;Li Xin;Feng Jun;Yue Zhi;Fu Hongxin;Wang Jufang,Engineering of Clostridium tyrobutyricum for butyric acid and butyl butyrate production from cassava starch.,Bioresource technology,2023
- Fu, Hongxin;Yang, Shang-Tian,Editorial: Development and Application of Clostridia as Microbial Cell-Factories for Biofuels and Biochemicals Production,Frontiers in Bioengineering and Biotechnology,2022
- Fu, Hongxin;Zhang, Huihui;Guo, Xiaolong;Yang, Lu;Wang, Jufang*,Elimination of carbon catabolite repression in Clostridium tyrobutyricum for enhanced butyric acid production from lignocellulosic hydrolysates,Bioresource Technology,2022
- Fu Hongxin;Yue Zhi;Feng Jun;Bao Teng;Yang Shang-Tian;Cai Youhua;Wang Jufang,Consolidated bioprocessing for butyric acid production from raw cassava starch by a newly isolated Clostridium butyricum SCUT620,Industrial Crops & Products,2022
- Feng, Jun;Guo, Xiaolong;Cai, Feifei;Fu, Hongxin;Wang, Jufang,Model-based driving mechanism analysis for butyric acid production in Clostridium tyrobutyricum,Biotechnology for Biofuels and Bioproducts,2022
- Fu Hongxin;Yang Lu;Zhang Huihui;Wang Jufang,Deciphering of the Mannitol Metabolism Pathway in Clostridium tyrobutyricum ATCC 25755 by Comparative Transcriptome Analysis.,Applied biochemistry and biotechnology,2022
- Fu, Hongxin;Luo, Sheng;Dai, Kaiqun;Qu, Chunyun;Wang, Jufang,Engineering Thermoanaerobacterium aotearoense SCUT27/Δldh with pyruvate formate lyase-activating protein (PflA) knockout for enhanced ethanol tolerance and production,Process Biochemistry,2021
- Fu Hongxin;Hu Jialei;Guo Xiaolong;Feng Jun;Yang Shang-Tian;Wang Jufang,Butanol production from Saccharina japonica hydrolysate by engineered Clostridium tyrobutyricum: The effects of pretreatment method and heat shock protein overexpression,Bioresource Technology,2021
- Lan, Yang;Feng, Jun;Guo, Xiaolong;Fu, Hongxin*;Wang, Jufang*,Isolation and characterization of a newly identified Clostridium butyricum strain SCUT343-4 for 1,3-propanediol production,Bioprocess and Biosystems Engineering,2021
- Fu, Hongxin;Lin, Meng;Tang, I-Ching;Wang, Jufang;Yang, Shang-Tian,Effects of benzyl viologen on increasing NADH availability, acetate assimilation, and butyric acid production by Clostridium tyrobutyricum,Biotechnology and Bioengineering,2021
- Fu, Hongxin*;Hu, Jialei;Guo, Xiaolong;Feng, Jun;Zhang, Yanan;Wang, Jufang*,High-Selectivity Butyric Acid Production from Saccharina japonica Hydrolysate by Clostridium tyrobutyricum,Industrial & Engineering Chemistry Research,2020
- Guo, Xiaolong;Fu, Hongxin;Feng, Jun;Hu, Jialei;Wang, Jufang,Direct conversion of untreated cane molasses into butyric acid by engineered Clostridium tyrobutyricum,Bioresource Technology,2020
- Fu Hongxin;Lin Meng;Tang IChing;Wang Jufang;Yang ShangTian,Effects of benzyl viologen on increasing NADH availability, acetate assimilation and butyric acid production by Clostridium tyrobutyricum.,Biotechnology and bioengineering,2020
- Fu, Hongxin;Yang, Xitong;Qu, Chunyun;Li, Yang;Wang, Jufang,Enhanced ethanol production from lignocellulosic hydrolysates by inhibiting the hydrogen synthesis in Thermoanaerobacterium aotearoense SCUT27(Δldh),Journal of Chemical Technology and Biotechnology,2019
- Suo, Yukai;Ren, Mengmeng;Yang, Xitong;Liao, Zhengping;Fu, Hongxin;Wang, Jufang,Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production with high butyrate/acetate ratio,Applied Microbiology and Biotechnology,2018
- Suo, Yukai;Fu, Hongxin;Ren, Mengmeng;Yang, Xitong;Liao, Zhengping;Wang, Jufang,Butyric acid production from lignocellulosic biomass hydrolysates by engineered Clostridium tyrobutyricum overexpressing Class I heat shock protein GroESL,Bioresource Technology,2018
- Luo, Ping;Zhang, Yanan;Suo, Yukai;Liao, Zhengping;Ma, Yi;Fu, Hongxin;Wang, Jufang,The global regulator IrrE from Deinococcus radiodurans enhances the furfural tolerance of Saccharomyces cerevisiae,Biochemical Engineering Journal,2018
- Suo, Yukai;Fu, Hongxin;Ren, Mengmeng;Liao, Zhengping;Ma, Yi;Wang, Jufang,Enhanced butyric acid production in Clostridium tyrobutyricum by overexpression of rate-limiting enzymes in the Embden-Meyerhof-Parnas pathway,Journal of Biotechnology,2018
- Liao, Zhengping;Suo, Yukai;Xue, Chuang;Fu, Hongxin;Wang, Jufang,Improving the fermentation performance of Clostridium acetobutylicum ATCC 824 by strengthening the VB1 biosynthesis pathway,Applied Microbiology and Biotechnology,2018
- Fu, Hongxin;Yu, Le;Lin, Meng;Wang, Jufang;Xiu, Zhilong;Yang, Shang-Tian,Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production from glucose and xylose,Metabolic Engineering,2017
- Fu, Hongxin;Yang, Shang-Tian;Wang, Minqi;Wang, Jufang;Tang, I-Ching,Butyric acid production from lignocellulosic biomass hydrolysates by engineered Clostridium tyrobutyricum overexpressing xylose catabolism genes for glucose and xylose co-utilization,Bioresource Technology,2017
- Fu, Hongxin;Wang, Xudong;Sun, Yaqin;Yan, Ling;Shen, Juntao;Wang, Jufang;Yang, Shang-Tian;Xiu, Zhilong,Effects of salting-out and salting-out extraction on the separation of butyric acid,Separation and Purification Technology,2017
出版专著和教材
专利
- 王菊芳;李艳梅;马毅;傅宏鑫;王蒙,一种人工合成抗菌肽及其应用,2022112211934,2025-11-04
- 王菊芳;李洋;傅宏鑫,一株产丁内酰胺的重组大肠杆菌及其构建方法与应用,2024119298340,2025-03-28
- 王菊芳;刘子尧;傅宏鑫,一种能够合成GABA的酪丁酸梭菌基因工程菌及其构建方法与应用,2023102047209,2024-12-20
- 王菊芳;程志敏;傅宏鑫;马毅,一种能表达外源蛋白的菌株、重组人源胶原蛋白及合成方法与应用,2024106270898,2024-09-13
- 王菊芳;郭晓龙;傅宏鑫,一种生产丁酸丁酯的酪丁酸梭菌重组菌株及其构建方法和应用,2021115983621,2023-07-18
- 王菊芳;刘苏;马毅;傅宏鑫;王蒙,一种重组人源融合胶原蛋白及其高效羟基化方法与应用,202210567560X,2023-06-16
- 傅宏鑫;王菊芳;任梦梦,一种提高嗜热厌氧杆菌发酵性能的方法,2019107517030,2023-04-21
- 王菊芳;兰洋;冯骏;傅宏鑫;张凌蔚,一种丁酸梭菌及其在固定化发酵生产1，3-丙二醇的应用,2020112390526,2022-10-21
- 王菊芳;王蒙;马毅;傅宏鑫,一种抗菌肽天蚕素A突变体及其编码基因、制备方法和应用,201810868364X,2021-05-14
- 王菊芳;冯骏;傅宏鑫,一种丁酸梭菌及其应用,2019105107900,2021-03-30
- 王菊芳;傅宏鑫;廖正平,一株耐受多种纤维素水解液抑制物的丙酮丁醇梭菌及其制备方法和应用,2018111730044,2021-01-19
- 王菊芳;程志敏;傅宏鑫;马毅,一种能表达外源蛋白的菌株、重组人源胶原蛋白及合成方法与应用,PCT/CN2024/123611,/
- 傅宏鑫;于智鑫;王菊芳,一种高产4′-N-demethyl-vicenistatin的方法,202310731141X
- 傅宏鑫;莫永章;王菊芳,一种产1,3-丙二醇的酪丁酸梭菌重组菌株及其构建方法和应用,2023115774396
- 傅宏鑫;南辰辰;王菊芳,一种重组毕赤酵母菌株及其构建方法和应用,2025104670068
- 王菊芳;叶发婷;冯骏;郭晓龙;傅宏鑫,一种共利用葡萄糖和木糖生产丁酸丁酯的酪丁酸梭菌及其构建方法和应用,2025114254410
- 傅宏鑫;程佳乐;王菊芳,一种生产乙酸丁酯的重组酪丁酸梭菌及其构建方法和应用,2025115938094
获奖、荣誉称号
软著
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- 游离DNA甲基化率预测软件[简称：FRAGMP]V1.0,软著登字第12657443号,2024SR0253570,2024-02-08 00:00:00