Biography
Dr. Fu primarily focuses on the creation and application of Clostridium-based cell factories. His research involves developing genetic manipulation platforms and genome-scale metabolic models for Clostridium, and employing synthetic biology enabling technologies to engineer Clostridium chassis cells for the efficient production of various chemicals (such as butyric acid, lactic acid, butanol, butyl butyrate, 1,3-propanediol, γ-aminobutyric acid, etc.) from industrial and agricultural waste (e.g., lignocellulose, molasses, crude glycerol, marine biomass) and carbon dioxide. He has undertaken and completed 10 research projects, including those funded by the National Natural Science Foundation of China, the Guangdong Key R&D Program (sub-project), the Guangdong Natural Science Foundation, and the Guangzhou Applied Basic Research Program. He has published 58 SCI papers in journals such as Chemical Engineering Journal, Metabolic Engineering, Biotechnology and Bioengineering, Separation and Purification Technology, and Bioresource Technology, and holds 10 authorized invention patents. Currently, he serves as an editorial board member for Discover Applied Sciences and Frontiers in Chemical Engineering, and as a reviewer for over 30 SCI journals.
Education
Sep 2009 – Oct 2016: Ph.D. in Biochemical Engineering, Dalian University of Technology
Sep 2013 – Oct 2015: Joint Ph.D., The Ohio State University
Admission Information
Work Experience
Social Position
Research Areas
(1) Metabolic Engineering for Constructing High-Efficiency Production Strains
(2) Fermentative Production of Bio-based Chemicals and Biofuels from Low-cost Feedstocks
(3) Fermentation Process Control and Optimization
(4) Downstream Separation Processes for Bio-based Chemicals and Biofuels
Courses Taught
Microbiology, Literature Search and Practice, Integrated Experiment of Biotechnology, New Technologies in Microbial Manufacturing, Fundamentals of Life Sciences
Research Project
Selected Publications
- Fu, Hongxin*;Li, Xin;Guo, Xiaolong;Yang, Die;Nan, Chenchen;Cheng, Jiale;Du, Haoming;Shen, Mengju;Wang, Jufang*,Consolidated bioprocessing of cassava starch into butyric acid and butanol by engineered Clostridium butyricum SCUT 620,Bioresource Technology,2025
- Mo, Yongzhang;Guo, Xiaolong;Lan, Yang;Wang, Jufang;Fu, Hongxin,Systems Metabolic Engineering of Clostridium tyrobutyricum for 1,3-Propanediol Production From Crude Glycerol,Biotechnology and Bioengineering,2025
- Guo, Xiaolong;Li, Xin;Feng, Jun;Yue, Zhi;Fu, Hongxin*;Wang, Jufang*;Guo Xiaolong;Li Xin;Feng Jun;Yue Zhi;Fu Hongxin*;Wang Jufang,Engineering of Clostridium tyrobutyricum for butyric acid and butyl butyrate production from cassava starch,Bioresource Technology,2024
- Fu, Hongxin*;Yang, Die;Li, Xin;Guo, Xiaolong;Mo, Yongzhang;Wang, Sheng;Wang, Jufang*,Metabolic and process engineering of Clostridium tyrobutyricum for efficient hydrogen production from sugarcane molasses,Fuel,2024
- Guo, Xiaolong;Ye, Fating;Nan, Chenchen;Cheng, Jiale;Feng, Jun;Fu, Hongxin*;Wang, Jufang,Efficient production of butyl butyrate from mannitol by engineered Clostridium tyrobutyricum,Chemical Engineering Journal,2024
- Guo, Xiaolong;Ding, Yuqing;Chen, Yufan;Fu, Hongxin*;Wang, Jufang*,Microbial cell factory for butyl butyrate production: Knowledges and perspectives,Microbial Biotechnology,2024
- Guo, Xiaolong;Ye, Fating;Nan, Chenchen;Cheng, Jiale;Feng, Jun;Fu, Hongxin*;Wang, Jufang,Efficient production of butyl butyrate from mannitol by engineered Clostridium tyrobutyricum,Chemical Engineering Journal,2024
- Dai, Kaiqun;Miao, Yuanhao;Qu, Chunyun;Wang, Cheng;Fu, Hongxin*;Wang, Jufang*,Adaptive laboratory evolution of Thermoanaerobacterium aotearoense for enhanced ethanol production from raw cassava starch,Renewable Energy,2024
- Guo Xiaolong;Zhang Huihui;Feng Jun;Yang Lu;Luo Kui;Fu Hongxin;Wang Jufang,De novo biosynthesis of butyl butyrate in engineered Clostridium tyrobutyricum,Metabolic Engineering,2023
- Fu, Hongxin;Yang, Lu;Zhang, Huihui;Wang, Jufang,Deciphering of the Mannitol Metabolism Pathway in Clostridium tyrobutyricum ATCC 25755 by Comparative Transcriptome Analysis,Applied Biochemistry and Biotechnology,2023
- Dai, Kaiqun;Qu, Chunyun;Feng, Jun;Lan, Yang;Fu, Hongxin*;Wang, Jufang*;Dai Kaiqun;Qu Chunyun;Feng Jun;Lan Yang;Fu Hongxin;Wang Jufang,Metabolic engineering of Thermoanaerobacterium aotearoense strain SCUT27 for biofuels production from sucrose and molasses,Biotechnology for Biofuels and Bioproducts,2023
- Guo Xiaolong;Li Xin;Feng Jun;Yue Zhi;Fu Hongxin;Wang Jufang,Engineering of Clostridium tyrobutyricum for butyric acid and butyl butyrate production from cassava starch.,Bioresource technology,2023
- Fu, Hongxin;Yang, Shang-Tian,Editorial: Development and Application of Clostridia as Microbial Cell-Factories for Biofuels and Biochemicals Production,Frontiers in Bioengineering and Biotechnology,2022
- Fu, Hongxin;Zhang, Huihui;Guo, Xiaolong;Yang, Lu;Wang, Jufang*,Elimination of carbon catabolite repression in Clostridium tyrobutyricum for enhanced butyric acid production from lignocellulosic hydrolysates,Bioresource Technology,2022
- Fu Hongxin;Yue Zhi;Feng Jun;Bao Teng;Yang Shang-Tian;Cai Youhua;Wang Jufang,Consolidated bioprocessing for butyric acid production from raw cassava starch by a newly isolated Clostridium butyricum SCUT620,Industrial Crops & Products,2022
- Feng, Jun;Guo, Xiaolong;Cai, Feifei;Fu, Hongxin;Wang, Jufang,Model-based driving mechanism analysis for butyric acid production in Clostridium tyrobutyricum,Biotechnology for Biofuels and Bioproducts,2022
- Fu Hongxin;Yang Lu;Zhang Huihui;Wang Jufang,Deciphering of the Mannitol Metabolism Pathway in Clostridium tyrobutyricum ATCC 25755 by Comparative Transcriptome Analysis.,Applied biochemistry and biotechnology,2022
- Fu, Hongxin;Luo, Sheng;Dai, Kaiqun;Qu, Chunyun;Wang, Jufang,Engineering Thermoanaerobacterium aotearoense SCUT27/Δldh with pyruvate formate lyase-activating protein (PflA) knockout for enhanced ethanol tolerance and production,Process Biochemistry,2021
- Fu Hongxin;Hu Jialei;Guo Xiaolong;Feng Jun;Yang Shang-Tian;Wang Jufang,Butanol production from Saccharina japonica hydrolysate by engineered Clostridium tyrobutyricum: The effects of pretreatment method and heat shock protein overexpression,Bioresource Technology,2021
- Lan, Yang;Feng, Jun;Guo, Xiaolong;Fu, Hongxin*;Wang, Jufang*,Isolation and characterization of a newly identified Clostridium butyricum strain SCUT343-4 for 1,3-propanediol production,Bioprocess and Biosystems Engineering,2021
- Fu, Hongxin;Lin, Meng;Tang, I-Ching;Wang, Jufang;Yang, Shang-Tian,Effects of benzyl viologen on increasing NADH availability, acetate assimilation, and butyric acid production by Clostridium tyrobutyricum,Biotechnology and Bioengineering,2021
- Fu, Hongxin*;Hu, Jialei;Guo, Xiaolong;Feng, Jun;Zhang, Yanan;Wang, Jufang*,High-Selectivity Butyric Acid Production from Saccharina japonica Hydrolysate by Clostridium tyrobutyricum,Industrial & Engineering Chemistry Research,2020
- Guo, Xiaolong;Fu, Hongxin;Feng, Jun;Hu, Jialei;Wang, Jufang,Direct conversion of untreated cane molasses into butyric acid by engineered Clostridium tyrobutyricum,Bioresource Technology,2020
- Fu Hongxin;Lin Meng;Tang IChing;Wang Jufang;Yang ShangTian,Effects of benzyl viologen on increasing NADH availability, acetate assimilation and butyric acid production by Clostridium tyrobutyricum.,Biotechnology and bioengineering,2020
- Fu, Hongxin;Yang, Xitong;Qu, Chunyun;Li, Yang;Wang, Jufang,Enhanced ethanol production from lignocellulosic hydrolysates by inhibiting the hydrogen synthesis in Thermoanaerobacterium aotearoense SCUT27(Δldh),Journal of Chemical Technology and Biotechnology,2019
- Suo, Yukai;Ren, Mengmeng;Yang, Xitong;Liao, Zhengping;Fu, Hongxin;Wang, Jufang,Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production with high butyrate/acetate ratio,Applied Microbiology and Biotechnology,2018
- Suo, Yukai;Fu, Hongxin;Ren, Mengmeng;Yang, Xitong;Liao, Zhengping;Wang, Jufang,Butyric acid production from lignocellulosic biomass hydrolysates by engineered Clostridium tyrobutyricum overexpressing Class I heat shock protein GroESL,Bioresource Technology,2018
- Luo, Ping;Zhang, Yanan;Suo, Yukai;Liao, Zhengping;Ma, Yi;Fu, Hongxin;Wang, Jufang,The global regulator IrrE from Deinococcus radiodurans enhances the furfural tolerance of Saccharomyces cerevisiae,Biochemical Engineering Journal,2018
- Suo, Yukai;Fu, Hongxin;Ren, Mengmeng;Liao, Zhengping;Ma, Yi;Wang, Jufang,Enhanced butyric acid production in Clostridium tyrobutyricum by overexpression of rate-limiting enzymes in the Embden-Meyerhof-Parnas pathway,Journal of Biotechnology,2018
- Liao, Zhengping;Suo, Yukai;Xue, Chuang;Fu, Hongxin;Wang, Jufang,Improving the fermentation performance of Clostridium acetobutylicum ATCC 824 by strengthening the VB1 biosynthesis pathway,Applied Microbiology and Biotechnology,2018
- Fu, Hongxin;Yu, Le;Lin, Meng;Wang, Jufang;Xiu, Zhilong;Yang, Shang-Tian,Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production from glucose and xylose,Metabolic Engineering,2017
- Fu, Hongxin;Yang, Shang-Tian;Wang, Minqi;Wang, Jufang;Tang, I-Ching,Butyric acid production from lignocellulosic biomass hydrolysates by engineered Clostridium tyrobutyricum overexpressing xylose catabolism genes for glucose and xylose co-utilization,Bioresource Technology,2017
- Fu, Hongxin;Wang, Xudong;Sun, Yaqin;Yan, Ling;Shen, Juntao;Wang, Jufang;Yang, Shang-Tian;Xiu, Zhilong,Effects of salting-out and salting-out extraction on the separation of butyric acid,Separation and Purification Technology,2017
Achievements
Patent
Honor
Software achievement