个人简介
教育经历
- 1989-09~1993-06,徐州师范学院
- ~2000-06,南开大学,无机化学,博士
招生信息
学术型博/硕导,医药生物学
专业学位博/硕导,生物与医药
工作经历
- 2004-03,华南理工大学
- 2004-03~2024-11,华南理工大学
- 2001-11~2003-11,日本金沢大学
- 2000-11~2001-11,法国Grenoble I 大学
社会、学会及学术兼职
教育部合成生物学与药物制备国际合作联合实验室 主任
广东省生物制药工程技术研究中心 主任
广东省药学会药物化学专业委员会 副主任委员
研究领域
新药研发与绿色生物制造
开授课程
本科生教学：《当代科技与生物制药》、大学城通选课《生物医药与健康》等
本科生导师制
研究生教学：《药物开发工艺设计与实践》，《现代药学概论》
科研项目
主持和参与包括国家自然科学基金在内的省部级项目9项，企业委托项目11项，目前在研项目6个，重点进行抗耐药抗生素新药及其荧光探针，乳腺癌抗体药物、胆酸系列产品和氨基酸类药物的研究。
论文
- Chen, Lin;Yang, Zhonglin;Lu, Yue;Li, Shan;Tang, Dongjiang;Zhang, Lei,Tyramide signal amplification-based detection system: A novel approach to improve detection efficiency for circulating tumor cells,Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2026
- Mao, Wen-Jie;Wang, Tian-Tian;Chen, Lin;Zhang, Lei;Li, Shan,Synthesis and optical properties of tyramine-functionalized boron dipyrromethene dyes for cell bioimaging,Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2025
- Shi, Kun;Wang, Li;Zheng, Xiao-Min;Zhang, Zhe;Zhong, Fan;Sun, Zhen-Zhu;Mohany, Mohamed;Huang, Hai-Hui;Li, Jing;Li, Shan;Zhang, Lei,Metronidazole-ursodeoxycholic acid bifunctional antibacterial: A promising strategy to combat Clostridium difficile infection and prevent recurrence,European Journal of Medicinal Chemistry,2025
- Du, Zhen;Li, Hong;Kuang, Xiaoshuang;Zhang, Lei;Li, Shan,Semi-rational design and modification of imine reductases and their utilization for the synthesis of (S)-nornicotine,Bioorganic Chemistry,2025
- Zhang, Zhe;Liang, Ying-Cong;Li, Tong;Liu, Chao-Lin;Zhao, Yun-Hu;Li, Shan;Gu, Bing;Zhang, Lei*,Chemoenzymatic Synthesis of tert-Butyl ((3R, 6R)-6-methyl-piperidin-3-yl)carbamate: A Key Intermediate in Orexin Receptor Antagonist and IRAK4 Inhibitor,ChemistrySelect,2025
- Zhang, Da-Jun;Wu, Min;Zhao, Yun-Hu;Lin, Hong-Wei;Li, Shan;Zhang, Lei,Exploring the Structural Landscape of Sunitinib through Salt Formation with Dicarboxylic Acids and Its Effect on Hygroscopicity and Dissolvability,Crystal Growth & Design,2025
- Song, Ci;Zheng, Xiaomin;Zhou, Zhenru;Yu, Yundong;Zhang, Lei;Li, Shan,Enhanced Regioselectivity and Catalytic Activity on C7Hydroxylation of Lithocholic Acid to Produce Ursodeoxycholic Acid by Monooxygenase CYP107D1 Based on Semi-Rational Design,Biotechnology Journal,2025
- Zhou, Zhen-Ru;Deng, Fang-Zhi;Zhong, Yi-hua;Li, Shan;Dong, Chang-Zhi;Zhang, Lei,Engineering a 7β-hydroxylase from fusarium longipes for enhancement of ursodeoxycholic acid production,International Journal of Biological Macromolecules,2025
- Tang, Lin;Li, Minxiong;Bai, Changlin;Feng, Xuejin;Hu, Haiyang;Yao, Yufen;Li, Baiqing;Li, Hongwei;Qin, Guohong;Xi, Ning*;Lv, Genpin*;Zhang, Lei*,Discovery of benzoheterocyclic-substituted amide derivatives as apoptosis signal-regulating kinase 1 (ASK1) inhibitors,RSC Medicinal Chemistry,2024
- Zhang, Da-Jun;Chen, Quan-Xu;Lin, Hong-Wei;Miao, Rui-Juan;Li, Shan;Zhang, Lei*,Toltrazuril Polymorphs and the Effect on Hygroscopicity and Dissolution Rate,Crystal Growth & Design,2024
- Deng, Fangzhi;Zhou, Zhenru;Du, Zhen;Mohany, Mohamed;Wu, Qunyue;Liang, Weiyang;Zhang, Lei;Li, Shan,Engineering Regioselectivity of P450 BM3 Enables the Biosynthesis of Murideoxycholic Acid by 6β-Hydroxylation of Lithocholic Acid,Biotechnology Journal,2024
- Zhou Zhen-Ru;Liu Fen;Li Shan;Dong Chang-Zhi;Zhang Lei*,A fungal P450 enzyme from Fusarium equiseti HG18 with 7β-hydroxylase activity in biosynthesis of ursodeoxycholic acid,Journal of Steroid Biochemistry and Molecular Biology,2024
- Zhou, Zhen-Ru;Liu, Fen;Li, Shan;Dong, Chang-Zhi;Zhang, Lei,A fungal P450 enzyme from Fusarium equiseti HG18 with 7B-hydroxylase activity in biosynthesis of ursodeoxycholic acid,Journal of Steroid Biochemistry and Molecular Biology,2024
- Li Haiyan;Dai Wei;Qin Shuaishuai;Li Shan;Yu Yundong;Zhang Lei,Regio- and stereo-selective 1β-hydroxylation of lithocholic acid by cytochrome P450 BM3 mutants.,Biotechnology and bioengineering,2023
- Li, Haiyan;Dai, Wei;Qin, Shuaishuai;Li, Shan;Yu, Yundong;Zhang, Lei*,Regio- and stereo-selective 1β-hydroxylation of lithocholic acid by cytochrome P450 BM3 mutants,Biotechnology and Bioengineering,2023
- Lin Xing;Zhang Dajun;Li Jing;Zhang Lei,Catalyst- and solvent-free regioselective ring opening of aziridines with amines: application in the gram-scale synthesis of the α,β-diamino propionic derivative, aspergillomarasmine A.,Organic & biomolecular chemistry,2023
- Liu, Hui-Jie;Cao, Sheng-Tian;Wen, Bao-Ying;Han, Xue;Li, Yong;Li, Shan;Li, Jing*;Zhang, Lei*,Rotundic acid ameliorates non-alcoholic steatohepatitis via SREBP-1c/SCD1 signaling pathway and modulating gut microbiota (vol 99, 108065, 2021),International Immunopharmacology,2023
- Zhou, Zihong;Feng, Yahui;Xu, Yongbo;Wu, Shuming;Kou, Jingping;Hu, Yanqing;Zhang, Meng;Ling, Weijian;Zhang, Lei;Wang, Zhongqing,Development of a Robust and Scalable Process for the Large-Scale Preparation of Vilazodone,Organic Process Research & Development,2022
- Yang, Jianing;Hu, Xuejiao;Wang, Wenzhuo;Yang, Yujing;Zhang, Xinqiang;Fang, Wei;Zhang, Lei;Li, Shan;Gu, Bing,RT-LAMP assay for rapid detection of the R203M mutation in SARS-CoV-2 Delta variant,Emerging Microbes & Infections,2022
- Jiang Qiu-Yue;Lin Zhi-Long;Su Zhuo-Wei;Li Shan;Li Jing;Guan Su;Ling Yun;Zhang Lei,Peptide identification of hepatocyte growth-promoting factor and its function in cytoprotection and promotion of liver cell proliferation through the JAK2/STAT3/c-MYC pathway,European Journal of Pharmacology,2022
- Li Yong;He XuLin;Zhou LiPing;Huang XiaoZhong;Li Shan;Guan Su;Li Jing;Zhang Lei,Asiatic acid alleviates liver fibrosis via multiple signaling pathways based on integrated network pharmacology and lipidomics.,European journal of pharmacology,2022
出版专著和教材
专利
- 张雷;林兴;李晶;李杉,一种曲霉明A及其类似物的合成方法,2023105163061,2025-11-07
- 张雷;郑晓敏;张哲;李杉,噁二唑-甾体化合物、药物组合物和用途,2025106883177,2025-10-03
- 李杉;陆海霞;杜臻;张雷,酪氨酸解氨酶突变体及其在合成对香豆酸中的用途,2025107484865,2025-08-05
- 李杉;张哲;郑晓敏;张雷,一种侧链含噁二唑结构的甾体类FXR激动剂及其制备方法和应用,2024106958997,2025-03-28
- 李杉;林春燕;张雷,细胞色素P450酶突变体及其用途,2024112634425,2024-11-12
- 张雷;邓芳植;李杉,细胞色素P450 BM3突变体及其用途,2024112181105,2024-11-08
- 张雷;吴东升;师瑞;孟巨光,酪氨酸酶突变体及其用途,2024108552456,2024-10-01
- 李杉;邝小霜;张雷,一种亚胺还原酶突变体及其应用,2023117049781,2024-08-06
- 张雷;钟帆;石琨;李杉;李晶,一种胆汁酸-甲硝唑缀合物及其应用,2022115780602,2024-07-09
- 张雷;孔鹏;李杉;钟义华,一种酮还原酶突变体及其应用,2023111233610,2024-03-29
- 张雷;李彤;李杉,一种化学-生物酶耦合制备Ritlecitinib中间体的方法,202110997858X,2024-02-13
- 张雷;操建春;孔鹏;李杉,一种化学-酶法合成3α,7α,24R-三羟基胆甾醇的方法,2023107599198,2023-09-29
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