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Selected Publications
- Chen, Lin;Yang, Zhonglin;Lu, Yue;Li, Shan;Tang, Dongjiang;Zhang, Lei,Tyramide signal amplification-based detection system: A novel approach to improve detection efficiency for circulating tumor cells,Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2026
- Mao, Wen-Jie;Wang, Tian-Tian;Chen, Lin;Zhang, Lei;Li, Shan,Synthesis and optical properties of tyramine-functionalized boron dipyrromethene dyes for cell bioimaging,Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2025
- Shi, Kun;Wang, Li;Zheng, Xiao-Min;Zhang, Zhe;Zhong, Fan;Sun, Zhen-Zhu;Mohany, Mohamed;Huang, Hai-Hui;Li, Jing;Li, Shan;Zhang, Lei,Metronidazole-ursodeoxycholic acid bifunctional antibacterial: A promising strategy to combat Clostridium difficile infection and prevent recurrence,European Journal of Medicinal Chemistry,2025
- Du, Zhen;Li, Hong;Kuang, Xiaoshuang;Zhang, Lei;Li, Shan,Semi-rational design and modification of imine reductases and their utilization for the synthesis of (S)-nornicotine,Bioorganic Chemistry,2025
- Zhang, Zhe;Liang, Ying-Cong;Li, Tong;Liu, Chao-Lin;Zhao, Yun-Hu;Li, Shan;Gu, Bing;Zhang, Lei*,Chemoenzymatic Synthesis of tert-Butyl ((3R, 6R)-6-methyl-piperidin-3-yl)carbamate: A Key Intermediate in Orexin Receptor Antagonist and IRAK4 Inhibitor,ChemistrySelect,2025
- Zhang, Da-Jun;Wu, Min;Zhao, Yun-Hu;Lin, Hong-Wei;Li, Shan;Zhang, Lei,Exploring the Structural Landscape of Sunitinib through Salt Formation with Dicarboxylic Acids and Its Effect on Hygroscopicity and Dissolvability,Crystal Growth & Design,2025
- Song, Ci;Zheng, Xiaomin;Zhou, Zhenru;Yu, Yundong;Zhang, Lei;Li, Shan,Enhanced Regioselectivity and Catalytic Activity on C7Hydroxylation of Lithocholic Acid to Produce Ursodeoxycholic Acid by Monooxygenase CYP107D1 Based on Semi-Rational Design,Biotechnology Journal,2025
- Zhou, Zhen-Ru;Deng, Fang-Zhi;Zhong, Yi-hua;Li, Shan;Dong, Chang-Zhi;Zhang, Lei,Engineering a 7β-hydroxylase from fusarium longipes for enhancement of ursodeoxycholic acid production,International Journal of Biological Macromolecules,2025
- Tang, Lin;Li, Minxiong;Bai, Changlin;Feng, Xuejin;Hu, Haiyang;Yao, Yufen;Li, Baiqing;Li, Hongwei;Qin, Guohong;Xi, Ning*;Lv, Genpin*;Zhang, Lei*,Discovery of benzoheterocyclic-substituted amide derivatives as apoptosis signal-regulating kinase 1 (ASK1) inhibitors,RSC Medicinal Chemistry,2024
- Zhang, Da-Jun;Chen, Quan-Xu;Lin, Hong-Wei;Miao, Rui-Juan;Li, Shan;Zhang, Lei*,Toltrazuril Polymorphs and the Effect on Hygroscopicity and Dissolution Rate,Crystal Growth & Design,2024
- Deng, Fangzhi;Zhou, Zhenru;Du, Zhen;Mohany, Mohamed;Wu, Qunyue;Liang, Weiyang;Zhang, Lei;Li, Shan,Engineering Regioselectivity of P450 BM3 Enables the Biosynthesis of Murideoxycholic Acid by 6β-Hydroxylation of Lithocholic Acid,Biotechnology Journal,2024
- Zhou Zhen-Ru;Liu Fen;Li Shan;Dong Chang-Zhi;Zhang Lei*,A fungal P450 enzyme from Fusarium equiseti HG18 with 7β-hydroxylase activity in biosynthesis of ursodeoxycholic acid,Journal of Steroid Biochemistry and Molecular Biology,2024
- Zhou, Zhen-Ru;Liu, Fen;Li, Shan;Dong, Chang-Zhi;Zhang, Lei,A fungal P450 enzyme from Fusarium equiseti HG18 with 7B-hydroxylase activity in biosynthesis of ursodeoxycholic acid,Journal of Steroid Biochemistry and Molecular Biology,2024
- Li Haiyan;Dai Wei;Qin Shuaishuai;Li Shan;Yu Yundong;Zhang Lei,Regio- and stereo-selective 1β-hydroxylation of lithocholic acid by cytochrome P450 BM3 mutants.,Biotechnology and bioengineering,2023
- Li, Haiyan;Dai, Wei;Qin, Shuaishuai;Li, Shan;Yu, Yundong;Zhang, Lei*,Regio- and stereo-selective 1β-hydroxylation of lithocholic acid by cytochrome P450 BM3 mutants,Biotechnology and Bioengineering,2023
- Lin Xing;Zhang Dajun;Li Jing;Zhang Lei,Catalyst- and solvent-free regioselective ring opening of aziridines with amines: application in the gram-scale synthesis of the α,β-diamino propionic derivative, aspergillomarasmine A.,Organic & biomolecular chemistry,2023
- Liu, Hui-Jie;Cao, Sheng-Tian;Wen, Bao-Ying;Han, Xue;Li, Yong;Li, Shan;Li, Jing*;Zhang, Lei*,Rotundic acid ameliorates non-alcoholic steatohepatitis via SREBP-1c/SCD1 signaling pathway and modulating gut microbiota (vol 99, 108065, 2021),International Immunopharmacology,2023
- Zhou, Zihong;Feng, Yahui;Xu, Yongbo;Wu, Shuming;Kou, Jingping;Hu, Yanqing;Zhang, Meng;Ling, Weijian;Zhang, Lei;Wang, Zhongqing,Development of a Robust and Scalable Process for the Large-Scale Preparation of Vilazodone,Organic Process Research & Development,2022
- Yang, Jianing;Hu, Xuejiao;Wang, Wenzhuo;Yang, Yujing;Zhang, Xinqiang;Fang, Wei;Zhang, Lei;Li, Shan;Gu, Bing,RT-LAMP assay for rapid detection of the R203M mutation in SARS-CoV-2 Delta variant,Emerging Microbes & Infections,2022
- Jiang Qiu-Yue;Lin Zhi-Long;Su Zhuo-Wei;Li Shan;Li Jing;Guan Su;Ling Yun;Zhang Lei,Peptide identification of hepatocyte growth-promoting factor and its function in cytoprotection and promotion of liver cell proliferation through the JAK2/STAT3/c-MYC pathway,European Journal of Pharmacology,2022
- Li Yong;He XuLin;Zhou LiPing;Huang XiaoZhong;Li Shan;Guan Su;Li Jing;Zhang Lei,Asiatic acid alleviates liver fibrosis via multiple signaling pathways based on integrated network pharmacology and lipidomics.,European journal of pharmacology,2022
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