Biography
By developing novel bioinformatic analysis techniques and integrating multi-omics data, we investigate the mechanisms of epigenetics and 3D genomics in development and disease. As first or corresponding author (including co-author), I have published 15 papers in journals such as Genome Biology, Genome Research, Nucleic Acids Research, and PNAS. The research has been supported by funding from the Guangdong Youth Enhancement Program, the National Natural Science Foundation of China, and Guangzhou Science and Technology Projects. The findings were recognized as one of the Top Ten Major Advances in Chinese Agricultural Science in 2021.
Education
2008-08 ~ 2013-06, University of Chinese Academy of Sciences, Bioinformatics, Ph.D. 2004-08 ~ 2008-07, Shandong Normal University, Biological Sciences, B.S.
Research Areas
Research interests focus on genomics and epigenetics. The work centers on constructing gene regulatory networks and elucidating their mechanisms. This involves developing novel experimental and computational methods to resolve high-resolution 3D genome architecture, as well as clarifying the regulatory roles of epigenetic modifications in development and disease, including embryonic development, reproductive system disorders, and cellular stress response.
Selected Publications
- Dai, Yimei;Jiang, Yunyun;Cao, Canran;Xu, Yongtai;Lai, Siting;Zhu, Wenchao;Gao, Meng;Li, Feifei;He, Sicong;Xu, Jin,Scavenger endothelial cells alleviate tissue damage by engulfing toxic molecules derived from hemolysis,Proceedings of the National Academy of Sciences,2025
- Jingwen Liu, Xuelai Liu, Feifei Li, Yujie Wang, Liping Yang, Meijia Zhang, Xinyu He,Loss of med14 causes developmental malformations characteristic of VACTERL association by disrupting the Mediator complex,Genes & Diseases,2025
- He, Min;Li, Xiaoli;Xu, Bingxiang;Lu, Yinbo;Lai, Jingyi;Ling, Yiming;Liu, Huakai;An, Ziyang;Zhang, Wenqing;Li, Feifei,Reprogramming of 3D genome structure underlying HSPC development in zebrafish,Stem Cell Research & Therapy,2024
- Xu, Bingxiang;Gao, Xiaomeng;Li, Xiaoli;Li, Feifei;Zhang, Zhihua,Crosslinking intensity modulates the reliability and sensitivity of chromatin conformation detection at different structural levels,Communications Biology,2024
- Li, Xiaoli;An, Ziyang;Zhang, Wenqing;Li, Feifei,Phase Separation: Direct and Indirect Driving Force for High-Order Chromatin Organization,Genes,2023
- Xu, Bingxiang;Gao, Xiaomeng;Li, Xiaoli;Jia, Yan;Li, Feifei;Zhang, Zhihua,Cell cycle arrest explains the observed bulk 3D genomic alterations in response to long-term heat shock in K562 cells,Genome Research,2022
- Li, F., Wang, D., Song, R., Cao, C,The asynchronous establishment of chromatin 3D architecture during early development of in vitro fertilized and uniparental preimplantation pig embryos,Genome Biology,2020
- Cong Liu, Yiqun Zhang, Xiaoli Li, Yan Jia,Evidence of constraint in the 3D genome for trans-splicing in human cells,Sci China Life Sci,2020
- Junfeng Liu , Ziyang An,Episo: quantitative estimation of RNA 5-methylcytosine at isoform level by high-throughput sequencing of RNA treated with bisulfite,Bioinformatics,2019
- Li Feifei, An Ziyang,The Dynamic 3D Genome in Gametogenesis and Early Embryonic Development,Cells,2019
- Zhang, H., Li, F.,Characteristic arrangement of nucleosomes is predictive of chromatin interactions at kilobase resolution,Nucleic acids research,2017
- Li, F., Zhang, D., Li, Y., Jiang, D., Luo, S., Du, N., Chen, W., Deng, L.,Whole genome characterization of hepatitis B virus quasispecies with massively parallel pyrosequencing,Clinical microbiology and infection,2015
Honor
- 2021年中国农业科学十项重大进展,李飞飞，张治华，王艳芳等,2021
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