About
I am current Professor and PI of School of Medicine, South China University of Technology. I am serving as the Vice Chairman of the China Zebrafish Society and as a member of the Chinese Association for Blood Science. I earned my Bachelor and PhD from Sun Yat-sen University, completed a post-doctoc at HKUST, and held the position of Professor at Southern Medical University at 2011 and subsequently at South China University of Technology from 2018 till now. My research focuses on the hematopoietic regulation, primarily using zebrafish as a model system. By utilizing hematopoietic-deficient mutants acquired through forward and reverse genetics, I am interested in uncovering novel biological mechanisms underlying hematopoietic regulation, and in establishing related blood disease models for pathological and translational studies.
Education
EDUCATION: 2003-2008 Sun Yat-Sen University, Guangzhou, China, Ph.D. of Biology 1999-2003 Sun Yat-Sen University, Guangzhou, China, Bachelor of Biology
WorkExperience
2018-present South China University of Technology, School of Medicine. Principal Investigator, Professor 2011-2018 Southern Medical university, School of Basic Medical Sciences. Principal Investigator, Professor 2008-2011 The Hong Kong University of Science and Technology, Division of Life Science, Hongkong, China. Postdoctoral Research.
Social Position
I served as the vice chairman of the China Zebrafish Society and as a member of the Chinese Association for Blood Science. I supported by the National Natural Science Foundation of China, such as the excellent youth fund and the general fund.
Research
We mainly utilize zebrafish as a model and takes developmental biology as the core to focus on the hematopoietic regulation mechanism. Utilizing hematopoietic-deficient zebrafish mutants obtained by forward and reverse genetics, we unveiled some new biological mechanisms of hematopoietic regulation, and established several blood disease models for pathological and translational study.
Thesis
- 张译月,Cebp1 and Cebpβ transcriptional axis controls eosinophilopoiesis in zebrafish,Nature Communications
- 张译月,Assessing the efficacy and safety of gemcitabine-induced thrombocytopenia/neutropenia and thrombocytopenia interventions in zebrafish,Journal of Genetics and Genomics
- 张译月,Paclitaxel improvesthrombopoiesisintheabsenceof thrombopoietinreceptor(Mpl）,J Thromb Haemost
- 张译月,Supramolecular pyrrole radical cations for bacterial theranostics,Biomater. Sci.
- Lin, Qing;Zhou, Riyang;Meng, Panpan;Wu, Liangliang;Yang, Lian;Liu, Wenyu;Wu, Jiaye;Cheng, Yuhuan;Shi, Linjuan;Zhang, Yiyue,Establishment of a Bernard-Soulier syndrome model in zebrafish,Haematologica-The Hematology Journal,107
- Wen, Wanying;Chen, Jiakui;Zhou, Yuxin;Li, Gaofei;Zhang, Yiyue,Loss of Ripk3 attenuated neutrophil accumulation in a lipopolysaccharide-induced zebrafish inflammatory model,Cell Death Discovery,8
- Wu, Mei;Chen, Qi;Li, Jing;Xu, Yue;Lian, Junwei;Liu, Yongxiang;Meng, Ping;Zhang, Yiyue,Gfi1aa/Lsd1 Facilitates Hemangioblast Differentiation Into Primitive Erythrocytes by Targeting etv2 and sox7 in Zebrafish,Frontiers in Cell and Developmental Biology,9
- Yang, Lian;Wu, Liangliang;Meng, Panpan;Zhang, Xuebing;Zhao, Dejian;Lin, Qing*;Zhang, Yiyue*;Yang L.;Wu L.;Meng P.;Zhang X.;Zhao D.;Lin Q.;Zhang Y.,Generation of a thrombopoietin-deficient thrombocytopenia model in zebrafish,Journal of Thrombosis and Haemostasis,20
- Lin, Qing;Lian, Junwei;Wu, Jiaye;Meng, Panpan;Sun, Ying;Wu, Liangliang;Zhang, Yiyue*,Erythropoietin receptor contributes to thrombopoietin receptor (Mpl)-independent thrombocytopoiesis in zebrafish,Leukemia,36
- Wu Mei;Chen Qi;Li Jing;Xu Yue;Lian Junwei;Liu Yongxiang;Meng Ping;Zhang Yiyue,Gfi1aa/Lsd1 Facilitates Hemangioblast Differentiation Into Primitive Erythrocytes by Targeting etv2 and sox7 in Zebrafish,Frontiers in Cell and Developmental Biology,9
- Yang Lian;Wu Liangliang;Meng Panpan;Zhang Xuebing;Zhao Dejian;Lin Qing;Zhang Yiyue,Generation of a thrombopoietin-deficient thrombocytopenia model in zebrafish.,Journal of thrombosis and haemostasis : JTH
- Huang Zhibin;Chen Kemin;Chi Yali;Jin Hao;Li Li;Zhang Wenqing;Xu Jin;Zhang Yiyue,Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb,J Biol Chem
- 张译月,Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish. ,Sci China Life Sci
- Huang, Zhibin;Chen, Kemin;Chi, Yali;Jin, Hao;Li, Li;Zhang, Wenqing;Xu, Jin;Zhang, Yiyue,Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb,JOURNAL OF BIOLOGICAL CHEMISTRY,296
- Chen, Jiakui;Li, Gaofei;Lian, Junwei;Ma, Ning;Huang, Zhibin;Li, Jianchao;Wen, Zilong;Zhang, Wenqing;Zhang, Yiyue,Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish,Science China Life Sciences,64
- Wu, Mei;Xu, Yue;Li, Jing;Lian, Junwei;Chen, Qi;Meng, Ping;Lu, Ting;Xie, Huafeng;Zhang, Wenqing;Xu, Jin;Zhang, Yiyue,Genetic and epigenetic orchestration of Gfi1aa-Lsd1-cebpa in zebrafish neutrophil development,Development,148
- Gao, Shuo;Wang, Zixuan;Wang, Luxiang;Wang, Haihong;Yuan, Hao;Liu, Xiaohui;Chen, Saijuan;Chen, Zhu;de The, Hugues;Zhang, Wenqing;Zhang, Yiyue;Zhu, Jun;Zhou, Jun,Irf2bp2a regulates terminal granulopoiesis through proteasomal degradation of Gfi1aa in zebrafish,PLoS Genetics,17
- Zhao, Yan;Wu, Mei;Li, Jing;Meng, Ping;Chen, Jiakui;Huang, Zhibin;Xu, Jin;Wen, Zilong;Zhang, Wenqing;Zhang, Yiyue,The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway,Cell Death & Disease,12
- Li, Jing;Meng, Panpan;Zhou, Riyang;Zhang, Yiyue*;Lin, Qing*,Famciclovir leads to failure of hematopoiesis, but may have the benefit of relieving myeloid expansion in MDS-like zebrafish,Toxicology and Applied Pharmacology,410
- Zhao Yan;Wu Mei;Li Jing;Meng Ping;Chen Jiakui;Huang Zhibin;Xu Jin;Wen Zilong;Zhang Wenqing;Zhang Yiyue,The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway.,Cell death & disease,12
- Lin Qing;Zhou Riyang;Meng Panpan;Wu Liangliang;Yang Lian;Liu Wenyu;Wu Jiaye;Cheng Yuhuan;Shi Linjuan;Zhang Yiyue,Establishment of a Bernard-Soulier syndrome model in zebrafish.,Haematologica
- Huang Zhibin;Chen Kemin;Chi Yali;Jin Hao;Li Li;Zhang Wenqing;Xu Jin;Zhang Yiyue,Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb,Journal of Biological Chemistry,296
- Wu Mei;Xu Yue;Li Jing;Lian Junwei;Chen Qi;Meng Ping;Lu Ting;Xie Huafeng;Zhang Wenqing;Xu Jin;Zhang Yiyue,Genetic and epigenetic orchestration of Gfi1aa-Lsd1-cebpa in zebrafish neutrophil development.,Development (Cambridge, England),148
- 张译月,Famciclovir leads to failure of hematopoiesis, but may have the benefit of relieving myeloid expansion in MDS-like zebrafish. ,Toxicology and Applied Pharmacology
- 张译月,The synergistic role of Pu.1 and Fms in zebrafish osteoclast reducing osteopetrosis and possible therapeutic strategies.,J Genet Genomics.,9
- 张译月,Keto-Salicylaldehyde Azine: A Kind of Novel Building Block for AIEgens and Its Application in Tracking Lipid Droplets.,Materials Chemistry Frontiers
- Liu, Wei;Di, Qianqian;Li, Kailun;Li, Jing;Ma, Ning;Huang, Zhibin;Chen, Jiahao;Zhang, Sheng;Zhang, Wenqing;Zhang, Yiyue,The synergistic role of Pu.1 and Fms in zebrafish osteoclast-reducing osteopetrosis and possible therapeutic strategies,Journal of Genetics and Genomics,47
- Zhou, Fan;Zhang, Kexin;Li, Gaofei;Gui, Chen;Hu, Rong;Li, Shiwu;Wang, Zhiming;Zhang, Yiyue;Tang, Ben Zhong,Keto-salicylaldehyde azine: a kind of novel building block for AIEgens and its application in tracking lipid droplets,Materials Chemistry Frontiers,4
- Li Jing;Meng Panpan;Zhou Riyang;Zhang Yiyue;Lin Qing,Famciclovir leads to failure of hematopoiesis, but may have the benefit of relieving myeloid expansion in MDS-like zebrafish.,Toxicology and applied pharmacology,410
- Lian, Junwei;Chen, Jiakui;Wang, Kun;Zhao, Lingfeng;Meng, Ping;Yang, Liting;Wei, Jiayi;Ma, Ning;Xu, Jin;Zhang, Wenqing;Zhang, Yiyue,Alas1 is essential for neutrophil maturation in zebrafish,Haematologica-The Hematology Journal,103
- Zhang, Zili;Liu, Wei;Zhao, Lingfeng;Huang, Zhibin;Chen, Xiaohui;Ma, Ning;Xu, Jin;Zhang, Wenqing;Zhang, Yiyue,Retinoblastoma 1 protects T cell maturation from premature apoptosis by inhibiting E2F1,Development,145
- Liu, W;Wu, M;Huang, Z;Lian, J;Chen, J;Wang, T;Leung, A Y H;Liao, Y;Zhang, Z;Liu, Q;Yen, K;Lin, S;Zon, Li;Wen, Z;Zhang, Y;Zhang, W,c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish,Leukemia,31
- Di, Qianqian;Lin, Qing;Huang, Zhibin;Chi, Yali;Chen, Xiaohui;Zhang, Wenqing;Zhang, Yiyue,Zebrafish nephrosin helps host defence against Escherichia coli infection,Open Biology,7
- Jin, Hao;Huang, Zhibin;Chi, Yali;Wu, Mei;Zhou, Riyang;Zhao, Lingfeng;Xu, Jin;Zhen, Fenghua;Lan, Yahui;Li, Li;Zhang, Wenqing;Wen, Zilong;Zhang, Yiyue,c-Myb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish,Blood,128
Patent
- 林青;张译月;杨练;吴亮亮,一种先天性血小板减少综合征的斑马鱼模型及其应用,2022105107635,2023-04-21
- 张译月;林青;周日阳;孟盼盼;吴亮亮,一种巨大血小板综合征的斑马鱼模型,2021105543023,2022-10-25
- 张译月;林青;李静;孟盼盼,抗病毒药物在制备治疗骨髓增生异常综合征药物中的应用及制得的骨髓增生异常综合征药物,2020110184806,2022-02-15
- 刘伟;张译月;张文清;黄志斌,一种双突变斑马鱼在制备骨硬化症动物模型中的应用,202010919904X,2021-08-10
- 张译月;林青;孟盼盼;刘文玉,紫杉醇类药物在制备治疗血小板减少症药物中的应用及治疗血小板减少症药物,2023111519143
- 林青;张译月;凌艺铭;吴家业;刘雨时,一种epoa基因突变致红系减少的斑马鱼模型及其应用,2024102097611
- 张译月;林青;邓嘉龙;周紫媛,一种化疗诱发的血液毒性斑马鱼模型及其应用,2024108394630
Honor
PRIZE 2017，“The excellent scholar award of the Chinese Society of Zebrafish. 2019，“the 8th Youth Science and Technology Award” of the Chinese Zoological Society.
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