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Zhangyiyue

Professor,

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Email: mczhangyy@scut.edu.cn

Department: South China University of Technology

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  • About
  • Education
  • Admission Information
  • Work Experience
  • Social Position
  • Research Field
  • Open Course
  • Research Project
  • Thesis
  • Achievements
  • Patent
  • Honor
  • Research Direction

About

I am current Professor and PI of School of Medicine, South China University of Technology. I am serving as the Vice Chairman of the China Zebrafish Society and as a member of the Chinese Association for Blood Science. I earned my Bachelor and PhD from Sun Yat-sen University, completed a post-doctoc at HKUST, and held the position of Professor at Southern Medical University at 2011 and subsequently at South China University of Technology from 2018 till now. My research focuses on the hematopoietic regulation, primarily using zebrafish as a model system. By utilizing hematopoietic-deficient mutants acquired through forward and reverse genetics, I am interested in uncovering novel biological mechanisms underlying hematopoietic regulation, and in establishing related blood disease models for pathological and translational studies.


Education

EDUCATION:

2003-2008     Sun Yat-Sen University, Guangzhou, China, Ph.D. of Biology

1999-2003     Sun Yat-Sen University, Guangzhou, China, Bachelor of Biology


Admission Information

WorkExperience

2018-present  South China University of Technology, School of Medicine.

                     Principal Investigator, Professor

2011-2018    Southern Medical university, School of Basic Medical Sciences.

                     Principal Investigator, Professor

2008-2011      The Hong Kong University of Science and Technology, Division of Life Science, Hongkong, China. Postdoctoral Research.


Social Position

I served as the vice chairman of the China Zebrafish Society and as a member of the Chinese Association for Blood Science. I supported by the National Natural Science Foundation of China, such as the excellent youth fund and the general fund.


Research

We mainly utilize zebrafish as a model and takes developmental biology as the core to focus on the hematopoietic regulation mechanism. Utilizing hematopoietic-deficient zebrafish mutants obtained by forward and reverse genetics, we unveiled some new biological mechanisms of hematopoietic regulation, and established several blood disease models for pathological and translational study.


Open Course

Research Project

Thesis

1.       Panpan Meng, Wenyu Liu, Jiawen Lao, Xunwei Liu, Yangping Zhang, Ying Sun, Riyang Zhou, Changhong Du, Junping Wang, Dejian Zhao, Qing Lin*, Yiyue Zhang*. Paclitaxel improves thrombopoiesis in the absence of thrombopoietin receptor (Mpl). J Thromb Haemost. (2024) https://doi.org/10.1016/j.jtha.2024.08.025

2.       Jialong Deng1, Ziyuan Zhou1, Wangjun Liao, Qing Lin*, Yiyue Zhang*. Assessing the efficacy and safety of gemcitabine-induced thrombocytopenia/neutropenia and thrombocytopenia interventions in zebrafish. Journal of Genetics and Genomics 51 (2024) 970-973

3.       Gaofei Li1, Yicong Sun1, Immanuel Kwok, Liting Yang, Wanying Wen, Peixian Huang, Mei Wu, Jing Li, Zhibin Huang, Zhaoyuan Liu, Shuai He, Wan Peng, Jin-Xin Bei,Florent Ginhoux, Lai Guan Ng*, Yiyue Zhang*. Cebp1 and Cebpβ transcriptional axis controls eosinophilopoiesis in zebrafish. Nat Commum. 15, Article number: 811 (2024) (IF=16.6, JCR:Q1) https://doi.org/10.1038/s41467-024-45029-0

4.       Yue Han1, Jing Li1, Lihua Zheng1, Yunhua Chen, Yan Yang*, Kai Liu*, Yiyue Zhang*, Meng Gao*, Supramolecular pyrrole radical cations for bacterial theranostics，Biomater. Sci., 2024, 12, 199. (IF=6.6, JCR:Q1)

5.       Lian Yang1, Liangliang Wu1, Panpan Meng, Xuebing Zhang, Dejian Zhao, Qing Lin#, Yiyue Zhang#. Generation of a thrombopoietin-deficient thrombocytopenia model in zebrafish, J Thromb Haemost. 2022;00:1-10. doi:10.1111/jth.15772  (2022.5，JCR Q1, IF 16.036)

6.       Qing Lin*, Riyang Zhou*, Panpan Meng*, Liangliang Wu, Lian Yang, Wenyu Liu, Jiaye Wu, Yuhuan Cheng, Linjuan Shi, Yiyue Zhang#. Establishment of a Bernard-Soulier syndrome model in zebrafish. Haematologica, 2022 Jul 1;107(7):1655-1668. doi: 10.3324/haematol.2021.278893. (2022.7，JCR Q1, IF9.941)

7.       Qing Lin*, Junwei Lian*, Jiaye Wu, Panpan Meng, Ying Sun, Liangliang Wu, Yiyue Zhang#. Erythropoietin receptor contributes to thrombopoietin receptor (Mpl)-independent thrombocytopoiesis in zebrafish. Leukemia. 2022 Apr;36(4):1193-1197.  https://doi.org/10.1038/s41375-021-01495-9  (2022.1.18，JCR Q1, IF 12.883)

8.       Wanying Wen, Jiakui Chen, Yuxin Zhou, Gaofei Li#, Yiyue Zhang#. Loss of Ripk3 attenuated neutrophil accumulation in a lipopolysaccharide-induced zebrafish inflammatory model. Cell Death Discov. 8, 88 (2022). https://doi.org/10.1038/s41420-022-00891-z  (2022.2.26，JCR Q2, IF 7.109)

9.       Mei Wu, Qi Chen, Jing Li, Yue Xu, Junwei Lian, Yongxiang Liu, Ping Meng, Yiyue Zhang. Gfi1aa/Lsd1 facilitates hemangioblast differentiation into primitive erythrocytes by targeting etv2 and sox7 in zebrafish. Frontiers in Cell and Developmental Biology. (2022) doi: 10.3389/fcell.2021.786426 (2022.1.12, JCR Q1 IF 6.684)

10.    Yan Zhao*, Mei Wu*, Jing Li, Ping Meng, Jiakui Chen, Zhibin Huang, Jin Xu, Zilong Wen, Wenqing Zhang#, and Yiyue Zhang#. The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway. Cell Death & Disease. 12, 906 (2021). https://doi.org/10.1038/s41419-021-04215-4(2021.10.5，JCR Q1, IF9.685)

11.    Mei Wu*, Yue Xu*, Jing Li, Junwei Lian, Qi Chen, Ping Meng, Ting Lu, Huafeng Xie, Wenqing Zhang, Jin Xu and Yiyue Zhang#. Genetic and epigenetic orchestration of Gfi1aa-Lsd1-cebpa in zebrafish neutrophil development. Development, 2021 Sep 1;148(17):dev199516. doi: 10.1242/dev.199516. Epub 2021 Sep 3 (2021.8.10 online, 2021.9.3 published, Q1, IF 6.862)

12.    Shuo Gao*, Zixuan Wang*, Luxiang Wang*, Haihong Wang*, Hao Yuan, Xiaohui Liu, aijuan Chen, Zhu Chen, Hugues de Thé, Wenqing Zhang, Yiyue Zhang#, Jun Zhu#, Jun Zhou#. Irf2bp2a regulates terminal granulopoiesis through proteasomal degradation of Gfi1aa in zebrafish. PLoS Genetics, (2021) Published: August 5, 2021 https://doi.org/10.1371/journal.pgen.1009693窗体顶端窗体底端 (2021.8.5 online, Q1, IF 6.02)

13.    Jiakui Chen*, Gaofei Li*, Junwei Lian, Ning Ma, Zhibing Huang, Jing Li, Zilong Wen, Wenqing Zhang#, and Yiyue Zhang#.(2021). Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish. Sci China Life Sci64, https://doi.org/10.1007/s11427-020-1878-8  (2021.3.16, Q1, IF 10.372)

14.    Zhibin Huang*, Kemin Chen*, Yali Chi, Hao Jin, Li Li, Wenqing Zhang, Jin Xu, Yiyue Zhang#. Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb, J Biol Chem, 2021 Jan 9;100272.   (2021.1.9, Q2, IF 5.486)

15.    Jing Li, Panpan Meng, Riyang Zhou, Yiyue Zhang#, Qing Lin# (2021) Famciclovir leads to failure of hematopoiesis, but may have the benefit of relieving myeloid expansion in MDS-like zebrafish. Toxicology and Applied Pharmacology, 2021 Jan 1;410:115334. doi: 10.1016/j.taap.2020.115334.  (2020.11.15 epub Q1, IF 4.46)

16.    Wei Liu, Qianqian Di, Kailun Li, Jing Li, Ning Ma, Zhibin Huang, Jiahao Chen, Sheng Zhang, Wenqing Zhang#, Yiyue Zhang#. (2020) The synergistic role of Pu.1 and Fms in zebrafish osteoclast reducing osteopetrosis and possible therapeutic strategies. J Genet Genomics. 47(9)：535-546. Q2, 5.723

17.    Fan Zhou1, Kexin Zhang1, Gaofei Li, Chen Gui, Rong Hu, Shiwu Li, Zhiming Wang#, Yiyue Zhang#  and  Ben Zhong Tang#. (2020) Keto-Salicylaldehyde Azine: A Kind of Novel Building Block for AIEgens and Its Applica   tion in Tracking Lipid Droplets. Materials Chemistry Frontiers, 2020,4, 3094-3102.  Q1, 8.683

18.    Meng P, Wu L, Lin Q#,  Zhang Y#.(2020). Zebrafish for thrombcoytopoiesis- and hemostasis-related researches and disorders. Blood Science. 2, 44-49 (Invited review)

19.    Zhang A, Wu M, Tan J, Yu N, Xu M, Yu X, Liu W, Zhang Y#.(2019) Establishment of a zebrafish hematological disease model induced by 1,4-benzoquinone. Disease Models & Mechanisms 12: dmm037903 Q2, 5.732

20.    Lian J, Chen J, Wang K, Zhao L, Meng P, Yang L, Wei J, Ma N, Xu J, Zhang W#, Zhang Y#. (2018) Alas1 is essential for neutrophil maturation in zebrafish. Haematologica. 2018 June:  haematol.2018.194316  Q1,9.941

21.    Zhang Z1, Liu W1, Zhao L, Huang Z, Chen X, Ma N, Xu J, Zhang W#, Zhang Y#.  (2018) Retinoblastoma 1 protects T cell maturation from premature apoptosis by inhibiting E2F1. Development. 2018: 145: dev158139   Q1, 6.862

22.    Lin, Q.1, Zhang, Y.1, Zhou, R., Zheng, Y., Zhao, L., Huang, M., Zhang, X., Leung, A.Y., Zhang, W., and Zhang, Y#. (2017). Establishment of a congenital amegakaryocytic thrombocytopenia model and a thrombocyte-specific reporter line in zebrafish. Leukemia. 31, 1206-1216. Q1, 12.883

23.    Liu, W.1, Wu, M.1, Huang, Z. 1, Lian J., Chen, J., Wang, T., Leung, A Y H., Liao, Y., Zhang, Z., Liu, Q., Yen, K., Lin, S,. Zon, Z L I., Wen, Z., Zhang, Y. #, Zhang, W #. (2017). c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish. Leukemia. 31, 222–233. Q1, 12.883

24.    Di Q1, Lin Q1, Huang Z, Chi Y, Chen X, Zhang W, Zhang Y#. (2017) Zebrafish nephrosin helps host defence against Escherichia coli infection. Open Biol. 2017 Aug;7(8). pii: 170040.  Q1, 7.124

25.    Jin, H.1, Huang, Z.1, Chi, Y., Wu, M., Zhou, R., Zhao, L., Xu, J., Zhen, F., Lan, Y., Li, L., Zhang, W., Wen, Z. #, Zhang, Y#. (2016) cMyb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish. Blood. 128, 415-426. Q1, 25.476

26.    Meng, P.1, Liu, Y.1, Chen, X., Zhang, W., Zhang, Y#. (2016). Zebrafish Cdh5 negatively regulates mobilization of aorta-gonad-mesonephros-derived hematopoietic stem cells. J Genet Genomics. 43, 613-616. Q1, 5.732

27.    Wang, K.1, Fang, X.1, Ma, N.1, Lin, Q., Huang, Z., Liu, W., Xu, M., Chen, X., Zhang, W. #, and Zhang, Y#.(2015). Myeloperoxidase-deficient zebrafish show an augmented inflammatory response to challenge with Candida albicans. Fish & shellfish immunology. 44, 109-116. Q1, 4.622

28.    Wang, K.1, Huang, Z.1, Zhao, L., Liu, W., Chen, X., Meng, P., Lin, Q., Chi, Y., Xu, M., Ma, N., Zhang, Y.#, Zhang W#. (2012). Large-scale forward genetic screening analysis of development of hematopoiesis in zebrafish. J Genet Genomics. 39, 473-480. Q1, 5.732


Achievements

Patent

Honor

PRIZE

2017，“The excellent scholar award of the Chinese Society of Zebrafish.

2019，“the 8th Youth Science and Technology Award” of the Chinese Zoological Society.


Software achievement